|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In CART analysis, the combined genotypes of FTO rs9939609 and TCF7L2 rs7903146 revealed the highest risk for BMI linked obesity.
|
27650258 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In recent years, the cocaine and amphetamine-regulated transcript (CART) peptides have generated a lot of interest in the battle against obesity because, via the brain, they exert anorexic effects and they increase energy expenditure.
|
27421727 |
2016 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Seven common polymorphisms in LEP, GHRL, CART and LEPR were analysed for genotype and haplotype association with anthropometric obesity phenotype indicators in South African Black and mixed-ancestry adolescent school learners.
|
21921635 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results supported the hypothesis that inherited variations of the CART gene could influence the development of obesity also in Italian children.
|
20151954 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subsequent studies on humans and transgenic animals provide additional evidence that CART is important in the regulation of appetite as mutations in the CART gene are linked to eating disorders, including obesity and anorexia.
|
16840648 |
2007 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A Leu34Phe mutation in the cocaine- and amphetamine-regulated transcript (CART) gene has been associated with severe early-onset obesity in an affected family.
|
16400624 |
2006 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the obesity observed in humans bearing the Leu34Phe mutation could be due to a putative deficiency in hypothalamic bioactive CART.
|
16210370 |
2006 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
However confirmation of the importance of the role of the CART gene in energy homeostasis and obesity will require investigation and replication in further populations.
|
15823203 |
2005 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent study also links a mutation in the CART gene to obesity in humans.
|
15519893 |
2004 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A missense mutation of G729C resulting in the substitution of Leu with Phe at codon 34, within the NH2-terminal CART region, has been detected in the heterozygous state in a 10-year-old obese boy who has been obese since the age of 2 years.
|
11522684 |
2001 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, we have conducted the first systematic study of the CART gene in human obesity, and although no clear association with obesity was found, the data suggest that genetic variation in the CART locus might influence fat distribution and variables related to syndrome X.
|
10905499 |
2000 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Radiation hybrid mapping co-localized the CART gene with a recently published human obesity locus at chromosome 5q13-14 corresponding also to an obesity locus at the similar syntenic region in mice.
|
10574510 |
1999 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|