|
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In transgenic animals, the deregulated expression of TCL1 leads to mature T cell leukemia, demonstrating the role of TCL1 in the initiation of malignant transformation in T cell neoplasia.
|
12011454 |
2002 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of the TCL1 oncogene has been implicated in T cell leukemias/lymphomas and recently was associated with AIDS diffuse large B cell lymphomas (AIDS-DLBCL).
|
11304575 |
2001 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This activation occurs as a result of translocations or inversions that cause rearrangement of the TCL1 (T-cell leukemia/lymphoma 1) locus with regulatory elements of T-cell receptor genes.
|
11710897 |
2001 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of TCL1 and/or TCL1b in mature T-cells causes T-cell leukemia in humans.
|
11607815 |
2001 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since the TCL6 gene was expressed in T-cell leukemia carrying a t(14;14)(q11;q32.1) chromosome translocation and was not expressed in normal T-cells (just like the TML1 and TCL1 genes), it is also a candidate gene potentially involved in leukemogenesis.Oncogene (2000).
|
10851082 |
2000 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TCL1 gene, localized near the break point of chromosome 14q32.1 often involved in T cell leukemias, is also expressed in normal precursor T and B cells, and B cell lymphoma cell lines.
|
10792782 |
2000 |
|
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region.
|
10077617 |
1999 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Introduction of a human TCL1 gene juxtaposed to the Ick promoter into fertilized mouse eggs resulted in the development of transgenic mice that developed mature T-cell leukemias, indicating that TCL1 is a transforming oncogene.
|
10197596 |
1999 |
|
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant TCL1 expression has been implicated in T cell leukemia/lymphoma development, and its expression also has been seen in many established B cell tumor lines.
|
10449776 |
1999 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lck-TCL1 transgenic mice developed mature T cell leukemias after a long latency period.
|
9520462 |
1998 |
|
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that TCL1 is not a major target gene for ATL, but that it may play a role in B-cell differentiation and proliferation.
|
9738977 |
1998 |
|
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, using molecular and immunocytochemical analysis, we report that TCL1 is also overexpressed in 10 of 10 ATL specimens, indicating that this gene may play an important role in the pathogenesis of this disease.
|
9407948 |
1997 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL).
|
7662982 |
1995 |
|
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The TCL-1 gene maps at chromosome 14q32.1 and is activated in T cell leukemias and lymphomas by either chromosome translocations or inversions that juxtapose the TCL-1 gene to the alpha/delta or the beta locus of the T cell receptor.
|
7987816 |
1994 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas.
|
7809072 |
1994 |
|
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TCL1 locus on chromosome 14 band q32.1 is frequently involved in the chromosomal translocations and inversions with the T-cell receptor genes observed in several T-cell tumors, including T-prolymphocytic leukemias, acute and chronic leukemias associated with the immunodeficiency syndrome ataxia-telangiectasia, and adult T-cell leukemia.
|
8415691 |
1993 |