Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways.
|
30151355 |
2018 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, we observed a fludarabine potentiation by SCH900776 in a T-cell leukemia 1 (TCL1)-driven mouse model of CLL.
|
27556692 |
2016 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and transgenic mouse studies indicate that activation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease.
|
27071132 |
2016 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pro-survival oncogene T-cell leukemia 1 (TCL1) is causally linked to the high threshold towards classical apoptosis in CLL.
|
26041471 |
2015 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia and dysregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene is a contributing event in the pathogenesis of the aggressive form of this disease based on transgenic mouse studies.
|
25646413 |
2015 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma protein 1 (TCL1) is expressed by several B-cell lymphomas, including MCL.
|
25688912 |
2015 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because immune-precipitation and mass spectrometry studies revealed that ROR1 could complex with T-cell leukemia 1 (TCL1) in CLL, we crossed these animals with Eµ-TCL1-Tg (TCL1) mice.
|
24379361 |
2014 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed the protein levels of AID splice isoforms by introducing an AID splice reporter construct into cell lines and primary CLL cells from patients as well as from WT and TCL1(tg) C57BL/6 mice (where TCL1 is T-cell leukemia/lymphoma 1).
|
24668151 |
2014 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas.
|
23160471 |
2013 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we determined whether T-cell leukemia/lymphoma 1 (TCL1) oncoprotein encoded by the TCL1 gene could be a target for immunotherapy of B-cell malignancies.
|
22645177 |
2012 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias.
|
22065599 |
2012 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell leukemia/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding to molecular subtypes, where poor-risk patients demonstrated higher expression levels.
|
19889012 |
2010 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human B-CLLs.
|
20357824 |
2010 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCL1 transgenic mice (TCL1-tg), in which TCL1 is ectopically expressed in mature lymphocytes, develop multiple B- and T-cell leukemia and lymphoma subtypes, supporting an oncogenic role for TCL1 that probably involves AKT and MAPK-ERK signaling pathway augmentation.
|
19147787 |
2009 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, unique gene expression profiles differentiating BL and DLBCL were reported and include higher transcript levels of T-cell leukemia-1 (TCL1) and CD38 and lower transcript levels of CD44 in MYC+ BL relative to MYC- DLBCL.
|
18162778 |
2008 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T-cell leukemia 1 (TCL1) oncoprotein is overexpressed by chromosomal rearrangement in the majority of cases of T-cell prolymphocytic leukemia (T-PLL).
|
17890451 |
2008 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deregulation of the T cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B cells causes a CD5-positive leukemia similar to aggressive human B-CLLs.
|
19064921 |
2008 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All expressed T-cell leukemia 1 (TCL-1) and CD7; cutaneous lymphocyte antigen expression was discernible in a dot-like perinuclear array.
|
16908353 |
2006 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated T-cell leukemia-1 (TCL1) oncoprotein expression might promote human Burkitt lymphoma (BL) because increased TCL1 causes Burkitt-like lymphomas in TCL1 transgenic mice.
|
16146820 |
2005 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q.
|
15661260 |
2005 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the t(14;14)(q11;q32) involving IGH at 14q32 in B-lineage ALL in our cases differ from those reported to involve the TCL1 gene on 14q32.1 in T-cell leukemia associated with AT.
|
15262434 |
2004 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mice from a transgenic mouse strain expressing the TCL1 gene under the thymocyte specific lck promoter developed a mature T cell leukemia late in life, thereby demonstrating that over-expression of TCL1 induces the neoplastic transformation of T cells.
|
12562214 |
2003 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protein product of the T-cell leukemia/lymphoma 1 (TCL1) oncogene was recently identified as a novel Akt kinase activator.
|
12962701 |
2003 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously discovered that the TCL1 (T-cell leukemia-1) proto-oncogene is expressed in a high proportion of AIDS-DLBCL compared to DLBCL cases and that aberrant TCL1 expression causes DLBCL in a new transgenic mouse model.
|
12710944 |
2003 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Induction of AKT serine/threonine kinase activity is augmented by the T-cell leukemia-1 (TCL1) oncoprotein through a physical association requiring the AKT pleckstrin homology domain.
|
12009899 |
2002 |