ISG15, ISG15 ubiquitin like modifier, 9636

N. diseases: 148; N. variants: 7
Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.050 Biomarker disease BEFREE The association between ISG15, OASL and IRF7 and TB infection was also verified. 31364746 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.050 Biomarker disease BEFREE In conclusion, this study identifies a novel anti-inflammatory ISG15/IL-10 myeloid axis that is disrupted in active TB. 29311364 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.050 Biomarker disease BEFREE These data raised the question of whether ISG15 may have diverse and sometimes opposing functions during M. tuberculosis infection. 28087453 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.050 AlteredExpression disease BEFREE Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. 26036210 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.050 Biomarker disease BEFREE Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. 26559095 2015