ISG15, ISG15 ubiquitin like modifier, 9636

N. diseases: 148; N. variants: 7
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE Certain classes of viruses encode Ub- or ISG15-specific proteases belonging to the ovarian tumor (OTU) superfamily. 28877473 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE Distinct structural determinants necessary for binding either substrate were identified and allowed the reengineering of the viral OTU protease into enzymes with increased substrate specificity, either for Ub or for ISG15. 21245344 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE These subtle differences in Ub/ISG15 binding allowed the design of vOTU variants specific for either Ub or ISG15, which will be useful tools to understand the relative contribution of ubiquitination vs. ISGylation in viral infection. 21266548 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 AlteredExpression disease BEFREE Thus, the deconjugating activity of viral OTU proteases represents a unique viral strategy to inhibit Ub- and ISG15-dependent antiviral pathways. 18078692 2007