ISG15, ISG15 ubiquitin like modifier, 9636

N. diseases: 148; N. variants: 7
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease BEFREE Host genetic polymorphisms, such as inosine triphosphatase (ITPA), interferon, lambda 3 (IFNL3), Q5 interferon, lambda 4 (IFNL4), toll-like receptors (TLRs) and interferon-stimulated gene 15 (ISG-15), were identified as key genes for treatment prediction and HCC evolution. 30614131 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression disease BEFREE Downregulation of ISG15 increased the sensitivity of HCC cells to norcantharidin, and norcantharidin treatment reversed the tumor-promoting effects of ISG15 overexpression exerted in HCC cells. 31611931 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression disease BEFREE miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells. 29758929 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease CTD_human HZ-6d targeted HERC5 to regulate p53 ISGylation in human hepatocellular carcinoma. 28919514 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease BEFREE ISG15 promotes the proliferation and migration of hepatocarcinoma cells through maintaining Survivin protein stabilization via sequestering XIAP from interacting with Survivin. 25238261 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression disease BEFREE Our results suggest that ISG15 overexpression could be developed into a powerful gene-therapeutic tool for treating IFN-α-resistant HCC. 24024201 2013