|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Role of CD81 and CD58 in minimal residual disease detection in pediatric B lymphoblastic leukemia.
|
29500862 |
2018 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
An anti-CD58 antibody identified residual leukemic cells (0.01% to 1.13%; median, 0.03%) in 9 of 104 bone marrow samples from children with ALL in clinical remission.
|
11264179 |
2001 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
In order to test this postulate, the expression of three important CAMs involved in tumor processes (CD44, ICAM-1 and LFA-3) in the human cancer cell lines HT29 (colon adenocarcinoma), A431 (squamous epidermal carcinoma) and A2780 (ovarian carcinoma) grown in monolayer or as multicellular spheroids was compared.
|
10470114 |
1999 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Subcutaneous inoculation of rV-LFA-3-infected murine colon adenocarcinoma tumor cells (MC38) into immunocompetent syngeneic C57BL/6 mice resulted in complete lack of tumor growth.
|
10094205 |
1999 |
|
Adenoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of HLA-A,B,C antigens and lymphocyte function-associated antigen 3 in human colorectal adenomas and adenocarcinomas was studied by immunohistochemistry.
|
2473473 |
1989 |
|
ADENOMAS AND ADENOCARCINOMAS
|
0.010 |
Biomarker
|
group |
BEFREE |
The expression of HLA-A,B,C antigens and lymphocyte function-associated antigen 3 in human colorectal adenomas and adenocarcinomas was studied by immunohistochemistry.
|
2473473 |
1989 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
An anti-CD58 antibody identified residual leukemic cells (0.01% to 1.13%; median, 0.03%) in 9 of 104 bone marrow samples from children with ALL in clinical remission.
|
11264179 |
2001 |
|
Adult Burkitt Lymphoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Unlike that observed in certain Burkitt lymphoma (BL) cell lines that share the same surface phenotype (CD10+CD38+CD23-CD39-), the c-myc-transfected cells expressed lymphocyte function-associated (LFA) 1, LFA-3, and intercellular adhesion molecule 1 and grew in large clumps rather than single-cell layers.
|
7836923 |
1995 |
|
Adult Burkitt Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Low expression of lymphocyte function-associated antigen (LFA)-1 and LFA-3 adhesion molecules is a common trait in Burkitt's lymphoma associated with and not associated with Epstein-Barr virus.
|
1691936 |
1990 |
|
Adult Burkitt Lymphoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Previous investigations carried out on EBV-positive Burkitt lymphoma (BL) cells have shown that this fact may be partially accounted for by a lack of expression of ICAM1 (CD54) and LFA3 (CD58).
|
1372880 |
1992 |
|
Adult Burkitt Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Secondly, we studied the sensitivity of BL to EBV-specific HLA class I-restricted CTL using a BL target line which was LFA-3- but which expressed the same spectrum of EBV target proteins as an LCL.
|
1378014 |
1992 |
|
Adult Burkitt Lymphoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Other activation antigens were unaffected by EBNA-2 expression, as were markers already expressed on the parent BL cell line, including BL markers (cALLA and BLA), proliferation markers (transferrin receptor and BK19.9), and cell adhesion-related molecules (LFA-1 and LFA-3).
|
3033649 |
1987 |
|
Adult Classical Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, we report frequent inactivating mutations of CD58 in cHL cell lines, but their rare occurrence in primary HRS cells.
|
26194173 |
2015 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.
|
22137796 |
2011 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors.
|
27825110 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we identified several lncRNA-TF-gene triplets (including HOTAIR-MXI1-CD58/PRKCE and HOTAIR-ATF5-NCAM1) that are associated with glioblastoma prognosis.
|
26943771 |
2016 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD58 protein expression as determined by flow cytometry, western blotting and immunohistochemistry was absent in all three mutated HL cell lines.
|
27467287 |
2016 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that genomic alteration of CD58, which is implicated in escape from the immunosurveillance mechanism, is more frequently observed in acute-type ATL than in the chronic-type.
|
25320005 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that genomic alteration of CD58, which is implicated in immune escape, is more frequently observed in acute than in chronic ATLL.
|
26550829 |
2015 |
|
Aspirin exacerbated respiratory disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This preliminary study suggests that CD58 does not affect AERD susceptibility in a Korean population, and may provide a new direction for future disease etiology.
|
21726122 |
2011 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Blockade or knockdown of Cd58 and Cd2 dramatically impaired the activation of antigen-specific Cd4<sup>+</sup> T and mIgM<sup>+</sup> B cells, followed by the inhibition of antibody production and host defense against bacterial infections.
|
29904386 |
2018 |
|
Bronchospasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of CD58 variations with aspirin-induced bronchospasm in Korean asthma patients.
|
21726122 |
2011 |
|
Burkitt Lymphoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Other activation antigens were unaffected by EBNA-2 expression, as were markers already expressed on the parent BL cell line, including BL markers (cALLA and BLA), proliferation markers (transferrin receptor and BK19.9), and cell adhesion-related molecules (LFA-1 and LFA-3).
|
3033649 |
1987 |
|
Burkitt Lymphoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Low expression of lymphocyte function-associated antigen (LFA)-1 and LFA-3 adhesion molecules is a common trait in Burkitt's lymphoma associated with and not associated with Epstein-Barr virus.
|
1691936 |
1990 |
|
Burkitt Lymphoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Previous investigations carried out on EBV-positive Burkitt lymphoma (BL) cells have shown that this fact may be partially accounted for by a lack of expression of ICAM1 (CD54) and LFA3 (CD58).
|
1372880 |
1992 |