Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Across different global populations and data sets, carriers of the MS risk allele showed reduced CD58 mRNA levels but increased hsa-miR-548ac levels.
|
30730892 |
2019 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The study suggests that genetic variants inGPC5, CD58 and IRF8 genes may be of clinical interest in MS as predictors of age of onset and response to therapy.
|
30818222 |
2019 |
Multiple Sclerosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Reduced CD58 expression is associated with risk for developing multiple sclerosis.
|
30418605 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In general, results from the current study indicate that CD226 and HLA-G, but not CD58 genetic polymorphisms are associated with increased risk of MS in Isfahan population similar to European populations.
|
30128676 |
2018 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Minor (C) variant of the single-nucleotide polymorphism (SNP) rs1335532 is associated with lower MS risk according to genome-wide association studies (GWAS) and its presence correlates with higher CD58 mRNA levels in MS patients.
|
30006149 |
2018 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
|
27386562 |
2016 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in CD48 have been linked to susceptibility to multiple sclerosis (MS), and altered expression of the structurally related protein CD58 (LFA-3) is associated with disease remission in MS. We examined CD48 expression and function in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We found that a subpopulation of CD4<sup>+</sup> T cells highly upregulated CD48 expression during EAE and were enriched for pathogenic CD4<sup>+</sup> T cells.
|
27581174 |
2016 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the first intron of CD58 have been independently confirmed to be related to the risk of MS. We here provide evidence that these SNPs may implicate an altered processing of an intronic microRNA.
|
25795118 |
2015 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study, cluster of differentiation 58 (CD58) region was found to be susceptible for the risk of multiple sclerosis (MS) in Caucasian, and the association between CD58 variants and MS was replicated in Americans.
|
24655566 |
2014 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
|
24234648 |
2014 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6.
|
22411505 |
2012 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine whether novel risk loci associated with systemic lupus erythematosus or multiple sclerosis may confer susceptibility to SSc, we tested single-nucleotide polymorphisms (SNP) from ITGAM, ITGAX, and CD58 for associations.
|
21362770 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13-14 in addition to the well established allele HLA-DR15.
|
20368992 |
2010 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
For example, nucleotide variation in the interleukin 7 receptor (IL7RA), the interleukin 2 receptor (IL2RA), the CD58 and the c-type lectin domain family 16 member A (CLEC16A) genes has been consistently associated with MS in several populations.
|
20450971 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, they imply that concentrations of susceptibility alleles at IL2RA, IL7R, EVI5, KIAA0350, and CD58 are partly responsible for the heightened prevalence of multiple sclerosis within multiplex families.
|
19506219 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |