Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results suggest that HDAC9 represents the disease-relevant gene at the stroke and coronary artery disease risk locus on 7p21.1, and that risk alleles in this region mediate their effects through increased HDAC9 expression.
|
25388417 |
2015 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) have indicated an association of histone deacetylase 9 (HDAC9) genetic variant with large-vessel stroke and coronary artery disease, among the European population.
|
27642596 |
2016 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A variant located at the end of HDAC9 gene within clusters of DNAse I sensitivity zones and histone modification hotspots has been associated with large vessel stroke and could be linked to plaque instability.
|
26621503 |
2016 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10<sup>-19</sup>; joint OR 1·37, 1·30-1·45, p=2·79 × 10<sup>-32</sup>) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10<sup>-7</sup>; joint OR 1·17, 1·11-1·23, p=2·29 × 10<sup>-10</sup>) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10<sup>-8</sup>; joint OR 1·24, 1·15-1·33, p=4·52 × 10<sup>-9</sup>) for large artery atherosclerosis stroke.
|
26708676 |
2016 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
HDAC9 gene region is a leading risk locus for large artery atherosclerotic stroke.
|
30031609 |
2018 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS.
|
26089329 |
2015 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This region on chromosome 7 has been previously associated with ischemic stroke and the large vessel stroke occlusive subtype (including HDAC9), suggesting a possible genetic link between this stroke subtype and IA.
|
25256182 |
2014 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
HDAC inhibitors were microinjected into the peri-infarct area 4 to 10 days after stroke.
|
28982677 |
2017 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genome-wide association studies have demonstrated various polymorphisms of histone deacetylase 9 (HDAC9) gene was strong risk locus for large-vessel stroke, but the results were controversial.
|
26347468 |
2016 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The results from our studies indicate HDAC9 gene is significantly associated with large-vessel stroke risk in Chinese population.
|
23828597 |
2013 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These results suggest that exposure to SVA, an inhibitor of HDAC, may be associated with a lower recurrent stroke risk although we cannot exclude residual confounding in this study design.
|
29247141 |
2018 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed.
|
23449258 |
2013 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)).
|
23041239 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In HDAC9 SNP rs2107595 risk allele-positive LVAS patients, there were 155 genes differentially expressed compared to risk allele-negative patients (fold change > ;1.2;, p < 0.05).
|
29651704 |
2019 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Now a recent GWAS published in Nature Genetics confirmed these previous associations, analyzed the specificity of the previous associations with particular stroke subtypes and identified a new association between HDAC9 and large vessel stroke.
|
22776031 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Background and Purpose- Genome-wide association studies have identified the <i>HDAC9</i> (histone deacetylase 9) gene region as a major risk locus for atherosclerotic stroke and coronary artery disease in humans.
|
31500558 |
2019 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Recent genome-wide association studies revealed that a genetic variant in the loci corresponding to histone deacetylase 9 (HDAC9) is associated with large vessel stroke.
|
25035344 |
2014 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value = .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P -value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value = .014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value = .036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level.
|
28975602 |
2018 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results indicated that HDAC9 polymorphisms may be used as biomarkers for susceptibility, severity, and short-term outcome of LAA stroke.
|
30565168 |
2019 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
|
28145521 |
2017 |
Mental Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
Together, these findings provide new insight into the underlying molecular mechanisms of depression and antidepressant action, and support the antidepressant potential of HDAC inhibitors and perhaps other agents that act at the level of chromatin structure.
|
19759294 |
2009 |
Mental Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
Some histone deacetylase (HDACs) enzymes have been proposed as epigenetic targets involved in the pathophysiology of depression and antidepressant-like action.
|
28778545 |
2017 |
Depressive disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Some histone deacetylase (HDACs) enzymes have been proposed as epigenetic targets involved in the pathophysiology of depression and antidepressant-like action.
|
28778545 |
2017 |
Depressive disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Together, these findings provide new insight into the underlying molecular mechanisms of depression and antidepressant action, and support the antidepressant potential of HDAC inhibitors and perhaps other agents that act at the level of chromatin structure.
|
19759294 |
2009 |