Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In HDAC9 SNP rs2107595 risk allele-positive LVAS patients, there were 155 genes differentially expressed compared to risk allele-negative patients (fold change > ;1.2;, p < 0.05).
|
29651704 |
2019 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Background and Purpose- Genome-wide association studies have identified the <i>HDAC9</i> (histone deacetylase 9) gene region as a major risk locus for atherosclerotic stroke and coronary artery disease in humans.
|
31500558 |
2019 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results indicated that HDAC9 polymorphisms may be used as biomarkers for susceptibility, severity, and short-term outcome of LAA stroke.
|
30565168 |
2019 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
HDAC9 gene region is a leading risk locus for large artery atherosclerotic stroke.
|
30031609 |
2018 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These results suggest that exposure to SVA, an inhibitor of HDAC, may be associated with a lower recurrent stroke risk although we cannot exclude residual confounding in this study design.
|
29247141 |
2018 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value = .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P -value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value = .014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value = .036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level.
|
28975602 |
2018 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
HDAC inhibitors were microinjected into the peri-infarct area 4 to 10 days after stroke.
|
28982677 |
2017 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In conclusion, this meta-analysis suggested that the T allele of rs2107595 in HDAC9 increases the risk of stroke but that the G allele of rs2389995 decreases the risk of stroke in the Chinese population.
|
28145521 |
2017 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies (GWAS) have indicated an association of histone deacetylase 9 (HDAC9) genetic variant with large-vessel stroke and coronary artery disease, among the European population.
|
27642596 |
2016 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A variant located at the end of HDAC9 gene within clusters of DNAse I sensitivity zones and histone modification hotspots has been associated with large vessel stroke and could be linked to plaque instability.
|
26621503 |
2016 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10<sup>-19</sup>; joint OR 1·37, 1·30-1·45, p=2·79 × 10<sup>-32</sup>) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10<sup>-7</sup>; joint OR 1·17, 1·11-1·23, p=2·29 × 10<sup>-10</sup>) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10<sup>-8</sup>; joint OR 1·24, 1·15-1·33, p=4·52 × 10<sup>-9</sup>) for large artery atherosclerosis stroke.
|
26708676 |
2016 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genome-wide association studies have demonstrated various polymorphisms of histone deacetylase 9 (HDAC9) gene was strong risk locus for large-vessel stroke, but the results were controversial.
|
26347468 |
2016 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Our results suggest that HDAC9 represents the disease-relevant gene at the stroke and coronary artery disease risk locus on 7p21.1, and that risk alleles in this region mediate their effects through increased HDAC9 expression.
|
25388417 |
2015 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS.
|
26089329 |
2015 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
|
26089329 |
2015 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This region on chromosome 7 has been previously associated with ischemic stroke and the large vessel stroke occlusive subtype (including HDAC9), suggesting a possible genetic link between this stroke subtype and IA.
|
25256182 |
2014 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Recent genome-wide association studies revealed that a genetic variant in the loci corresponding to histone deacetylase 9 (HDAC9) is associated with large vessel stroke.
|
25035344 |
2014 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The results from our studies indicate HDAC9 gene is significantly associated with large-vessel stroke risk in Chinese population.
|
23828597 |
2013 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed.
|
23449258 |
2013 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
GWASDB |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)).
|
23041239 |
2012 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Now a recent GWAS published in Nature Genetics confirmed these previous associations, analyzed the specificity of the previous associations with particular stroke subtypes and identified a new association between HDAC9 and large vessel stroke.
|
22776031 |
2012 |
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
CTD_human |
We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).
|
22306652 |
2012 |