HDAC4, histone deacetylase 4, 9759

N. diseases: 256; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.220 Biomarker disease RGD Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. 24717296 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.220 Therapeutic disease RGD Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. 24717296 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.220 Biomarker disease BEFREE The successful in vitro and in vivo delivery of siRNA, as well as targeted gene knockdown potential, was demonstrated by HDAC4 inhibition in vitro diabetic nephropathy (DN) podocyte model as well as in vivo DN C57BL/6 mice model. 31690769 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.220 AlteredExpression disease BEFREE Podocytes treated with high glucose, advanced glycation end products, or transforming growth factor-β (common detrimental factors in diabetic nephropathy) selectively increased HDAC4 expression. 24717296 2014
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Biomarker disease BEFREE We conclude that HDAC4 might be a useful target for the treatment of sepsis. 29988587 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Biomarker disease RGD Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. 23925573 2014
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. 19553350 2009
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic disease RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.130 Biomarker disease BEFREE HDAC4 could therefore represent a potential therapeutic target for the control and management of obesity and presumably insulin resistance. 24086512 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.130 Biomarker disease BEFREE As variants in the Hdac4 gene are associated with obesity in humans, our results indicate that the cAMP-HDAC4 pathway functions importantly in maintaining insulin sensitivity and energy balance via its effects on the innate immune system. 24768298 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.130 Biomarker disease HPO
CUI: C0028754
Disease: Obesity
Obesity 		0.130 AlteredExpression disease BEFREE The results revealed that methylation levels within HDAC4 and RAX2 loci were positively associated with obesity, while the methylation levels of loci within APOA5 and CES1 loci were negatively correlated with obesity. 29797594 2018
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.110 Biomarker disease BEFREE Recently, histone deacetylase 4 (HDAC4) haploinsufficiency has been postulated to be the critical genetic mechanism responsible for the main clinical characteristics of the BDMR syndrome like developmental delay and behavioural abnormalities in combination with brachydactyly type E (BDE). 23188045 2013
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.110 Biomarker disease HPO
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.100 Biomarker disease HPO
CUI: C0013336
Disease: Dwarfism
Dwarfism 		0.100 Biomarker disease HPO
CUI: C0013595
Disease: Eczema
Eczema 		0.100 Biomarker disease HPO
CUI: C0018777
Disease: Conductive hearing loss
Conductive hearing loss 		0.100 Biomarker disease HPO
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0025958
Disease: Microcephaly
Microcephaly 		0.100 Biomarker disease HPO
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.100 Biomarker disease HPO
CUI: C0038271
Disease: Stereotyped Behavior
Stereotyped Behavior 		0.100 Biomarker disease HPO
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.100 GeneticVariation disease GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
CUI: C0153535
Disease: Malignant melanoma of skin of upper limb
Malignant melanoma of skin of upper limb 		0.100 GeneticVariation disease GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
CUI: C0153536
Disease: Malignant melanoma of skin of lower limb
Malignant melanoma of skin of lower limb 		0.100 GeneticVariation disease GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018