Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE In addition, Lee index, left ventricular end-systolic, end-diastolic and left atrial diameter were significantly higher, GFR values were significantly lower in the group with cardiac events.Multivariate regression analysis showed that smoking (OR 5.031, 95% CI 1.602 to 15.794), presence of hypertension (OR 5.133, 95% CI 1.297 to 20.308) and aortic arch calcification (OR 6.920, 95% CI 3.890 to 12.310) are independent predictors of major cardiac events within 30-day of elective orthopedic surgery. 30595343 2020
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Estimated GFR was found to be significantly associated with faltering of height and hypertension. 30796705 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE The variables independently associated with ΔGFR were baseline body mass index (BMI) (positively), high blood pressure (HBP) (negatively), and fasting plasma glucose (FPG) (negatively), as well as FPG variation (positively). 30238213 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE <b>Results:</b> In the study group, GFR was 25.74 ± 8.94 mL/min/1.73 m<sup>2</sup>; 6 children were dialyzed; 26 had arterial hypertension. 31293181 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE In addition, 75% of albuminuria cases (P = .031), 83.3% of hypertension cases (P = .004), and 100% of decreased eGFRcases (P = .031) were significantly associated with CAKUT (renal parenchymal anomaly category), being the strongest predictor of GFR the presence or absence of CAKUT.Neonatal ultrasound screening is useful for the early diagnosis of SFK. 30095653 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Out of office BPs are especially important in patients with CKD, because reduced GFR and proteinuria are associated with masked hypertension (normal office BP and elevated BP outside of the office), elevated nighttime BP, and abnormal diurnal variation in BP, all of which are associated with higher risk for target organ damage and adverse outcomes. 29483139 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Well-controlled hypertension alone seems less relevant for outcomes, even if its effect is probably multiplicative if combined with low GFR and proteinuria. 29949013 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Diabetes is strongly associated with both albuminuria and reduced GFR independent of demographics and hypertension, contributing substantially to the burden of CKD in the United States. 29054846 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Preeclampsia is characterized by an increase in high blood pressure and decrease in GFR and proteinuria, however, the underlying mechanisms are still unclear. 27147460 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE We determined the incidence of diabetes in kidney donors, and compared GFR change over time in diabetic to nondiabetic donors, in addition to the effect of diabetes mellitus (DM) on the development of proteinuria, hypertension, and end-stage renal disease (ESRD). 28681494 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Abbreviations BMI = body mass index BP = blood pressure CH = hypertensive crisis ContrHT = controlled hypertensive DBP = diastolic blood pressure GFR = glomerular filtration rate HbA1c = glycated hemoglobin HDLc = high-density lipoprotein cholesterol HE = hypertensive emergency HPLC = high-performance liquid chromatography HR = heart rate HU = hypertensive urgency JNC 7 = VII Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure LDLc = low-density lipoprotein cholesterol MDRD = Modification of Diet in Renal Disease NT = normotensive RASB = renin-angiotensin system blockers SBP = systolic blood pressure TC = total cholesterol TG = triglycerides. 28569557 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Taking into account the effect of age, sex, duration of hypertension and other potentially confounding factors, in multiple regression analyses, only the association of GFR with ARD/H and that between GFR and ARD/BSA remained statistically significant. 27873227 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE This results in a higher SNeGFR in hypertensives compared with normotensive and CKD subjects, but lowered SNeGFR/VglomNSG in CKD subjects, suggesting that changes in GFR are accommodated by glomerular hypertrophy rather than glomerular hypertension. 28978800 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE There was a significant difference between CKD patients with hypertension and the subjects in the control group regarding systolic and diastolic BP, urea, creatinine, GFR, TG, cholesterol, LDL, HDL, and total antioxidant levels (p < 0.001). 27838804 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE Our study was a longitudinal observational study of 622 participants in the African American Study of Kidney Disease and Hypertension with APOL1 genotyping and sufficient follow-up for estimating GFR trajectories. 27230965 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE The frequent presentation of systemic hypertension and microalbuminuria with relatively preserved GFR coupled with the presence of polycythemia and hyperuricemia suggests a new clinical syndrome we term high altitude renal syndrome (HARS). 21566053 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE All patients had normal GFR.Most frequent long-term complications were hypertension (in seven of 15 patients) and osteoporosis in one third of patients. 19808243 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE However, after the data for GFR (main determinant for plasma homocysteine) was adjusted we observed that plasma homocysteine concentrations greater than 8.6 micro mol/l in patients with normal GFR are not related to vascular complications, but to hypertension (8.6-11.3 micro mol/l: OR 1.9; >11.3 micro mol/l: OR 3.7). 12242465 2002