Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Although decreased eGFR in type 2 diabetes patients was not prevalent, the strategies to prevent the progressive decline of GFR should be done to prevent patients from progressing to advanced renal disease. 31494076 2020
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m<sup>2</sup> This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. 31506289 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Even in the absence of a "measured" GFR, HF should be regarded as an early marker of Fabry nephropathy, and its recognition and confirmation by true GFR seems a relevant feature to address the issue of the potential benefit of nephroprotective treatments at the early stage of Fabry nephropathy. 30466100 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE No difference was observed between GFR at 1 year when comparing anuric to non-anuric transplant recipients of medical renal disease etiology. 31066481 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE The equations underestimated GFR when measured by Tc<sup>99</sup>m-DTPA (MDRD4-9.4 ± 25ml/min, P<.05, and CKD-EPI-4.4 ± 21ml/min). 28411971 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 GeneticVariation group BEFREE Uric acid was weakly associated with decline in GFR in type 1 diabetic patients with overt nephropathy. 29534864 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy. 29153995 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 GeneticVariation group BEFREE We aimed to quantify the associations between serum suPAR concentration and adverse outcomes in Black Americans with and without <i>APOL1</i> kidney disease risk variants, over and above iodine-125 iothalamate measured GFR and proteinuria. 29903900 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Measured results were compared with GFR estimates derived from estimation equations [4-variable Modification of Diet in Renal Disease, Cockcroft-Gault, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine, cystatin C and creatinine-cystatin C combined equations]. 28108166 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Abbreviations BMI = body mass index BP = blood pressure CH = hypertensive crisis ContrHT = controlled hypertensive DBP = diastolic blood pressure GFR = glomerular filtration rate HbA1c = glycated hemoglobin HDLc = high-density lipoprotein cholesterol HE = hypertensive emergency HPLC = high-performance liquid chromatography HR = heart rate HU = hypertensive urgency JNC 7 = VII Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure LDLc = low-density lipoprotein cholesterol MDRD = Modification of Diet in Renal Disease NT = normotensive RASB = renin-angiotensin system blockers SBP = systolic blood pressure TC = total cholesterol TG = triglycerides. 28569557 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Baseline GFR, estimated by the simplified Modification of Diet in Renal Disease equation, was stratified into ≤60, 61-90, and >90 mL/min/1.73 m2. 29045941 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Evaluation of GFR, required in the evaluation of living kidney donor candidates, is now receiving increasing emphasis because recent data demonstrate increased risk of kidney disease after donation, including a small increase in the risk of kidney failure. 28298325 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE GFR was estimated using the abbreviated Modification of Diet in Renal Disease Equation. 24311711 2014
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 GeneticVariation group BEFREE To determine thresholds for hyperuricemia and uric-acid excretion fraction (UAEF) according to GFR, these parameters were analyzed in 1097 patients with various renal diseases and renal function levels. 21868615 2011
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE The prevalence of hyperfiltration assessed by Modification of Diet in Renal Disease estimated GFR was 51%. 20185605 2010
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE The Ala-allele is associated with enhanced decline in GFR and predicts ESRD and all-cause mortality in patients with nephropathy. 18467141 2008
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE ACE inhibitors and angiotensin II receptor antagonists can be used in combination to maximize RAAS inhibition and more effectively reduce proteinuria and GFR decline in diabetic and nondiabetic renal disease. 16336578 2005
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE GFR was estimated using the simplified Modification of Diet in Renal Disease Study equation, and CRCL was estimated using the Cockcroft-Gault equation. 15339995 2004
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE In summary, an increase of Lp(a) concentrations, compared with apo(a) phenotype-matched control subjects, is seen in non-nephrotic patients with primary renal disease even in the earliest stage when GFR is not yet subnormal. 10616846 2000
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE In the Ramipril Efficacy in Nephropathy study, ramipril decreased the rate of GFR decline (deltaGFR) and progression to end-stage renal disease (ESRD) in 352 patients with proteinuric chronic nephropathies. 10616844 2000
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 GeneticVariation group BEFREE Chronic interstitial nephropathy with disproportionate hyperuricemia (serum uric acid 10.5-14.8 mg/dl [625-880 mumol/l] at a GFR of 40 ml/min/1.73 m2) was observed in 2 girls and their mother who suffered from gout since the age of 20 years. 6855996 1983