Furthermore, the association of two linked cytidine deaminase (CDA) promoter variants (c.1-451C>T: OR<sub>dominant</sub> = 4.3, 95% CI 1.3-14.2, P<sub>adjusted</sub> = 0.017; and c.1-92A>G: OR<sub>dominant</sub> = 4.4, 95% CI 1.3-14.5, P<sub>adjusted</sub> = 0.015) with Cp-related diarrhea was replicated.
The presence of two polymorphisms (CDD943insC and CES 2 Exon3 6046 G/A) were associated with a non-statistically significant higher incidence of grade 3 hand-foot syndrome (HFS) (p=0.07) and grade 3-4 diarrhoea (p=0.09), respectively.
Southern blot analysis was performed with a probe specific for the cda gene of pColD157 and two groups of EHEC O157:H7 isolates from patients with diarrhea or hemolytic-uremic syndrome resident in Germany.