|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
|
29326435 |
2019 |
|
body fat percentage (physical finding)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.
|
30593698 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
RESTING HEART RATE
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
|
29769521 |
2018 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
|
RESTING HEART RATE
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.
|
27798624 |
2016 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, IP6K1 knockout mice present increased insulin sensitivity and obesity resistance, indicating a novel therapeutic target in confronting insulin resistance.
|
29111280 |
2019 |
|
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
Unlike therapeutic interventions that target peroxisome proliferator-activated receptor gamma and leptin receptor activity, which yield detrimental side effects including increased fracture risk and altered feeding behavior, respectively, inhibition of IP6K1 maintains insulin sensitivity and prevents obesity while preserving bone integrity.
|
28577302 |
2017 |
|
Obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Global deletion of IP6K1 ameliorates obesity and insulin resistance irrespective of the environmental temperature conditions, which strengthens its validity as an anti-obesity target.
|
28123939 |
2017 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we examined if platelets and IP6K1 regulate pancreatic tissue injury via formation of NETs in experimental models of acute pancreatitis (AP) in mice.
|
31593553 |
2019 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Deletion of IP6K1 elicited several aberrations, including: 1, sloughing off of round germ cells; 2, disorientation and malformation of elongating/elongated spermatids; 3, degeneration of acrosomes; 4, defects in germ-Sertoli cell interactions and 5, failure of spermiation.
|
29728588 |
2018 |
|
Pneumonia, Bacterial
|
0.010 |
Biomarker
|
group |
BEFREE |
IP6K1-mediated inorganic polyphosphate (polyP) production by platelets was essential for infection-induced neutrophil-platelet aggregate (NPA) formation and facilitated neutrophil accumulation in alveolar spaces during bacterial pneumonia.
|
29618559 |
2018 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
The high K<sub>m</sub> for ATP of the IP<sub>7</sub>-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 and 2) suggests that these enzymes might serve as metabolic sensors in insulin secreting β-cells and act as translators of disrupted metabolism in diabetes.
|
29522819 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
The high K<sub>m</sub> for ATP of the IP<sub>7</sub>-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 and 2) suggests that these enzymes might serve as metabolic sensors in insulin secreting β-cells and act as translators of disrupted metabolism in diabetes.
|
29522819 |
2018 |
|
Deformity
|
0.010 |
Biomarker
|
group |
BEFREE |
Deletion of IP6K1 elicited several aberrations, including: 1, sloughing off of round germ cells; 2, disorientation and malformation of elongating/elongated spermatids; 3, degeneration of acrosomes; 4, defects in germ-Sertoli cell interactions and 5, failure of spermiation.
|
29728588 |
2018 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a result, IP6K1-KO mice are protected from DIO, insulin resistance, and fatty liver even at 30 °C.
|
28123939 |
2017 |
|
Congenital anomaly of brain
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We report that <i>IP6K1</i> deletion leads to brain malformation and abnormalities of neuronal migration.
|
28154132 |
2017 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a result, IP6K1-KO mice are protected from DIO, insulin resistance, and fatty liver even at 30 °C.
|
28123939 |
2017 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Not much is known about the functions of the equally abundant and ubiquitously expressed IP6K1 isoform in cell migration, invasion and cancer progression.
|
27140681 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our study therefore uncovers similarities and differences in the roles of IP6K1 and IP6K2 in cancer progression, and we propose that an isoform-specific IP6K1 inhibitor may provide a novel route to suppress carcinogenesis.
|
27140681 |
2016 |
|
Intraepithelial Neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
When fed an oral carcinogen, mice lacking IP6K1 show reduced progression from epithelial dysplasia to invasive carcinoma.
|
27140681 |
2016 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
|
27140681 |
2016 |
|
Invasive Carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, unlike IP6K2, IP6K1 is essential for 4NQO-induced invasive carcinoma.
|
27140681 |
2016 |