KEAP1, kelch like ECH associated protein 1, 9817

N. diseases: 251; N. variants: 4
Disease: Ureteral obstruction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.020 Biomarker phenotype BEFREE Treatment with 5-MTP ameliorates renal interstitial fibrosis, inhibits IκB/NF-κB signaling, and enhances Keap1/Nrf2 signaling in mice with UUO or ischemia/reperfusion injury, as well as in cultured human kidney cells. 30931940 2019
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.020 AlteredExpression phenotype BEFREE In CL and UUO, upregulation of nuclear (erythroid-derived 2)-like 2 transcription factor (Nrf2), as well as of cytoplasmic and nuclear Kelch-like ECH-associated protein 1 (Keap1) in opposition to decreased heme oxygenase-1 (HO-1), suggest impairment of the Nrf2/Keap1/HO-1 system. 31251767 2019