CDK1, cyclin dependent kinase 1, 983

N. diseases: 214; N. variants: 8
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 Biomarker disease BEFREE This study reveals that CDK1 activation induces vemurafenib resistance and that AD is a promising therapeutic strategy for colon cancer both as a single agent and in combination with vemurafenib. 30872078 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 Biomarker disease BEFREE Upregulation of CDK1/cdc2 accompanied by a malignant change was previously reported in colon cancer. 15317660 2004
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 PosttranslationalModification disease BEFREE Growth inhibition, cell cycle arrest, induction of p53 and p21 mRNA and protein, and cdc2 phosphorylation and kinase activity were studied in treated cells from the H460 lung cancer line and p21 and p53 knockout cells of the HCT 116 colon cancer line. 11705845 2001