Disease: Neoplasms, Intracranial ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527390
Disease: Neoplasms, Intracranial
Neoplasms, Intracranial 		0.020 Biomarker group BEFREE Here, we demonstrate that MELK depletion by shRNA diminishes the growth of GSC-derived mouse intracranial tumors in vivo, induces glial fibrillary acidic protein (+) glial differentiation of GSCs leading to decreased malignancy of the resulting tumors, and prolongs survival periods of tumor-bearing mice. 23339114 2013
CUI: C1527390
Disease: Neoplasms, Intracranial
Neoplasms, Intracranial 		0.020 Biomarker group BEFREE Treatment with the first-line chemotherapy agent for GBM, Temozolomide, paradoxically enriches for both FOXM1 (+) and MELK (+) cells in GBM cells, and addition of Siomycin A to Temozolomide treatment in mice harboring GSC-derived intracranial tumors enhances the effects of the latter. 23404835 2013