ELMO1, engulfment and cell motility 1, 9844

N. diseases: 72; N. variants: 31
Disease: Diabetes Mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 Biomarker group BEFREE Our data demonstrate that in diabetes mellitus ELMO1 is the "rate-limiting" factor of reactive oxygen species production via both Rac-dependent and Rac-independent NADPH oxidases, which in turn trigger cellular signaling cascades toward cardiomyopathy. 31217360 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 GeneticVariation group BEFREE The CCR5 59029G>A and ELMO1 (+9170 G>A) loci are more frequent, and the SLC12A3 34372 AA genotype is associated with a reduced risk of diabetes. 24433479 2014
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 Biomarker group BEFREE However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. 25169573 2014