|
melanoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our results indicate that SETDB1 is a major driver of melanoma development and may serve as a potential future target for the treatment of this disease.
|
31131878 |
2019 |
|
melanoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
We have reported that the increase in H3K9me3 is derived from the methyltransferases SETDB1 and SETDB2 following treatment in melanoma, lung, breast and colorectal cancer cell lines, as well as melanoma patient data.
|
30850015 |
2019 |
|
melanoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the potential association of p16(INK) (4A) promoter methylation with histone methyltransferase SETDB1 expression in Greek patients with sporadic melanoma and their correlation with clinicopathological characteristics.
|
24673285 |
2014 |
|
melanoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
The associated variants at the 1q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1.
|
21983785 |
2011 |
|
melanoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
The associated variants at the 1q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1.
|
21983785 |
2011 |
|
melanoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our studies establish SETDB1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis.
|
21430779 |
2011 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, SETDB1 might be associated with the development of bone metastases from PCa.
|
26846621 |
2016 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Silencing SETDB1 inhibited PCa cell proliferation, migration and invasion.
|
24556744 |
2014 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
SETDB1-dependent loop formations bypassed 0.2-1 Mb of linear genome and radiated from the TAD<sup>cPcdh</sup> fringes toward cis-regulatory sequences within the cPcdh locus, counterbalanced shorter-range facilitative promoter-enhancer contacts and carried loop-bound polymorphisms that were associated with genetic risk for schizophrenia.
|
28671686 |
2017 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
A diagnosis of schizophrenia is a significant predictor for increased GLP, SETDB1 mRNA expression and H3K9me2 levels in both postmortem brain and lymphocyte samples.
|
23815974 |
2013 |
|
Anhedonia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness.
|
20505083 |
2010 |
|
Anhedonia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.
|
20505083 |
2010 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Malignant mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.
|
26928227 |
2016 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
As such, the oncogenic function of SETDB1 in various cancers may be attributed to tumorigenesis, at least in part, through activating AKT.
|
31050579 |
2019 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we describe how overexpression of SETDB1 contributes to melanoma tumorigenesis.
|
31131878 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This functional study has shown that SETDB1 plays an important role in head and neck carcinogenesis.
|
31768101 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these findings reveal complicated layers of Akt activation regulation coordinated by SETDB1-mediated Akt K64 methylation to drive tumorigenesis.
|
30692626 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.
|
31320639 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer.
|
29901162 |
2018 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In human cancers, histone methyltransferase SETDB1 (SET domain, bifurcated 1) is frequently overexpressed but its significance in carcinogenesis remains elusive.
|
29897144 |
2018 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
For conclusion, our study indicated that SETDB1 is essential for colorectal carcinogenesis, and may be a newly target for treatment and prognostic evaluation in CRC.
|
29158805 |
2017 |
|
Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Aberrant histone methylation at H3K9 by SETDB1 promotes silencing of tumor suppressor genes and thus contributes to carcinogenesis.
|
28076698 |
2017 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we performed the yeast two hybrid approach to identify p63α interactors involved in breast tumorigenesis and we found that SETDB1, a histone lysine methyl transferases, interacts with ΔNp63α and that this interaction contributes to p63 protein stability.
|
26840455 |
2016 |