|
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.
|
26174813 |
2015 |
|
Multiple Myeloma
|
0.310 |
Biomarker
|
disease |
BEFREE |
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.
|
16044163 |
2005 |
|
Multiple Myeloma
|
0.310 |
Biomarker
|
disease |
CTD_human |
As a substantial number of multiple myeloma cell lines and primary samples were found to express AMPK-related protein kinase 5(ARK5), a member of the AMPK family associated with tumor growth and invasion, we examined whether dual inhibition of CDK4 and ARK5 kinases using ON123300 results in a better therapeutic outcome.
|
26873845 |
2016 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.
|
26213588 |
2015 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.
|
26873845 |
2016 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
As such, NUAK1 may play key roles in multiple diseases ranging from neurodegeneration to diabetes and metastatic cancer.
|
29106388 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study is to determine the roles of NUAK1 and miR-204 in the drug resistance and metastasis of liver cancer and to reveal their relationship.
|
30807203 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study is to determine the roles of NUAK1 (a downstream of Akt) and miR-204 in the invasiveness and metastasis of NSCLC and to reveal the correlation between NUAK1 and miR-204.
|
25412236 |
2014 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We identified ARK5 (AMPK-Related Protein Kinase 5, also referred to as NUAK Family Kinase 1) as a novel metabolic target present in all species, and independent analyses confirmed glucose metabolism as the most significantly aberrant cellular signaling pathway in a model system for highly metastatic tumors.
|
29100308 |
2017 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, only the ARK5-overexpressing PANC-1 cell line (P/ARK) tumor showed invasion and metastasis in nude mice, although Akt was activated in tumors derived from both P/ARK and its parental cell line.
|
15060171 |
2004 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ARK5 is found to play a role in ICC metastasis and regulating EMT.
|
31360102 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of ARK5 was able to significantly reduce the ability HCC cells to invade and metastasize.
|
29434843 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that NUAK1 was increased in the tumor of primary liver cancer.
|
30807203 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARK5 is a member of the human AMP-activated protein kinase (AMPK) family which is implicated in tumor survival and progression.
|
28469776 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumorigenicity and spontaneously metastatic capability regulated by ARK5 were determined using an orthotopic xenograft tumor model.
|
22105900 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report that a novel AMPK catalytic subunit family member, ARK5, plays a key role in tumor malignancy downstream of Akt.
|
15060171 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data point to a novel role for calcium in supporting tumour cell viability and clarify the synthetic lethal interaction between NUAK1 and MYC.
|
29106388 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AMPK-related kinase 5 (ARK5) is a member of the human AMP-activated protein kinase (AMPK) family, which is associated with increased tumor survival and drug resistance in many cancers.
|
30662653 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings have highlighted a novel role for NUAK1 in LKB1-related signaling pathways; NUAK1 can regulate cell proliferation and exert tumor suppression through direct interaction with p53.
|
21317932 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The activation of ARK5 is triggered by Akt, and ARK5 induces tumor cell survival during nutrient starvation.
|
13679856 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
|
26255969 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, SNHG6 induced EMT of BC cells by upregulating the expression levels of Snail1/2 and regulated BC cell migration and invasion by tumor suppressive hsa-miR-125b and its target gene NUAK Family Kinase 1 (NUAK1).
|
30168179 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our results suggest that NUAK1 plays an important role in NSCLC cell migration and invasion.
|
23215946 |
2013 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the role of ARK5 in invasion and metastasis of HCC cells remains unclear.
|
29434843 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of NUAK1 inhibited cell migration and invasion.
|
25412236 |
2014 |