Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The activation of ARK5 is triggered by Akt, and ARK5 induces tumor cell survival during nutrient starvation.
|
13679856 |
2003 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, only the ARK5-overexpressing PANC-1 cell line (P/ARK) tumor showed invasion and metastasis in nude mice, although Akt was activated in tumors derived from both P/ARK and its parental cell line.
|
15060171 |
2004 |
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Based on these observations, it is suggested that ARK5 expression is involved in cancer invasion and metastasis.
|
15354411 |
2004 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report that a novel AMPK catalytic subunit family member, ARK5, plays a key role in tumor malignancy downstream of Akt.
|
15060171 |
2004 |
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Based on these observations, it is suggested that ARK5 expression is involved in cancer invasion and metastasis.
|
15354411 |
2004 |
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, only the ARK5-overexpressing PANC-1 cell line (P/ARK) tumor showed invasion and metastasis in nude mice, although Akt was activated in tumors derived from both P/ARK and its parental cell line.
|
15060171 |
2004 |
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Based on these observations, it is suggested that ARK5 expression is involved in cancer invasion and metastasis.
|
15354411 |
2004 |
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we attempted to determine whether ARK5 is involved in tumor malignancy under regulation by Akt.
|
15060171 |
2004 |
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Based on these observations, it is suggested that ARK5 expression is involved in cancer invasion and metastasis.
|
15354411 |
2004 |
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we attempted to determine whether ARK5 is involved in tumor malignancy under regulation by Akt.
|
15060171 |
2004 |
Multiple Myeloma
|
0.310 |
Biomarker
|
disease |
BEFREE |
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.
|
16044163 |
2005 |
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, in ARK5 mRNA-expressing multiple myeloma lines, but not in ARK5-negative lines, insulin-like growth factor (IGF)-1 increased invasion activity.
|
16044163 |
2005 |
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ARK5, AMP-activated protein kinase (AMPK)-related protein kinase mediating Akt signals, is closely involved in tumor progression, and its stage-associated expression was observed in colorectal cancer.
|
16044163 |
2005 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ARK5, AMP-activated protein kinase (AMPK)-related protein kinase mediating Akt signals, is closely involved in tumor progression, and its stage-associated expression was observed in colorectal cancer.
|
16044163 |
2005 |
Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
Plasmacytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ARK5, AMP-activated protein kinase (AMPK)-related protein kinase mediating Akt signals, is closely involved in tumor progression, and its stage-associated expression was observed in colorectal cancer.
|
16044163 |
2005 |
Adult Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
Childhood Burkitt Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IGF-1-induced invasion was reproduced when ARK5 was overexpressed in Burkitt's lymphoma and plasmacytoma lines.
|
16044163 |
2005 |
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation.
|
16424013 |
2006 |
Malignant transformation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation.
|
16424013 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings have highlighted a novel role for NUAK1 in LKB1-related signaling pathways; NUAK1 can regulate cell proliferation and exert tumor suppression through direct interaction with p53.
|
21317932 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumorigenicity and spontaneously metastatic capability regulated by ARK5 were determined using an orthotopic xenograft tumor model.
|
22105900 |
2012 |
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Depletion of ARK5 prolongs survival in MYC-driven mouse models of hepatocellular carcinoma, demonstrating that targeting cellular energy homeostasis is a valid therapeutic strategy to eliminate tumour cells that express deregulated MYC.
|
22460906 |
2012 |
Secondary malignant neoplasm of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
In an in vivo study, we also demonstrated that ARK5-transfected breast cancer cells grew faster and had more pulmonary metastases than its parental counterparts.
|
22105900 |
2012 |