|
Cannabis use
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis of age at first cannabis use.
|
30003630 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
|
23144326 |
2012 |
|
Surfactant protein D measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
|
23144326 |
2012 |
|
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
|
18839057 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
|
18839057 |
2008 |
|
Language Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
There were associations with LI risk gene ATP2C2 and dyslexia risk gene MRPL19.
|
25448322 |
2015 |
|
Language Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
For example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are associated with typical forms of language impairment.
|
23228431 |
2013 |
|
Language Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s.
|
21457949 |
2011 |
|
Language Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We therefore propose that variants in CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment.
|
19646677 |
2009 |
|
Specific language impairment
|
0.020 |
Biomarker
|
disease |
BEFREE |
ATP2C2 is a known candidate gene for specific language impairment and is postulated to have neurobiological significance in memory-related circuits.
|
25296922 |
2015 |
|
Dyslexia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
There were associations with LI risk gene ATP2C2 and dyslexia risk gene MRPL19.
|
25448322 |
2015 |
|
Dyslexia
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study we investigate the role of variants in these genes (namely MRPL19/C20RF3, ROBO1, DCDC2, KIAA0319, DYX1C1, CNTNAP2, ATP2C2 and CMIP) in the aetiology of SLI and dyslexia.
|
21165691 |
2011 |
|
Specific language impairment
|
0.020 |
Biomarker
|
disease |
BEFREE |
This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition.
|
19646677 |
2009 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Based on these findings, we propose that SPCA2 functions as a key regulator of EMT and may be a potential therapeutic target for treatment of metastatic cancer.
|
31076498 |
2019 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Based on these findings, we propose that SPCA2 functions as a key regulator of EMT and may be a potential therapeutic target for treatment of metastatic cancer.
|
31076498 |
2019 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We show that E-cadherin is tightly coexpressed with the secretory pathway Ca<sup>2+</sup>-ATPase isoform 2, SPCA2 (<i>ATP2C2</i>), in breast tumors.
|
31076498 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Based on these findings, we propose that SPCA2 functions as a key regulator of EMT and may be a potential therapeutic target for treatment of metastatic cancer.
|
31076498 |
2019 |
|
Substance Use Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The significant association between age of initiation and ATP2C2 is consistent with the role of calcium signalling mechanisms in substance use disorders.
|
30003630 |
2018 |
|
Cocaine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although the five SNPs and ATP2C2 did not replicate, ATP2C2 has been associated with cocaine dependence in a previous study.
|
30003630 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dysregulation of the Golgi/Secretory Pathway Ca<sup>2+</sup> transport ATPase SPCA2 is implicated in breast cancer.
|
27692665 |
2017 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dysregulation of the Golgi/Secretory Pathway Ca<sup>2+</sup> transport ATPase SPCA2 is implicated in breast cancer.
|
27692665 |
2017 |
|
Pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNA analysis indicates that the decreased Atp2c2c expression observed early in experimental pancreatitis reflects a global molecular response of acinar cells to reduce cytosolic Ca(2+) levels.
|
27017909 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings reveal a signaling pathway in which the Orai1-SPCA2 complex elicits constitutive store-independent Ca(2+) signaling that promotes tumorigenesis.
|
20887894 |
2010 |