|
Hypertensive disease
|
0.340 |
AlteredExpression
|
group |
BEFREE |
Low estimated glomerular filtration rate (eGFR), OSR-1 gene expression, total kidney volume (TKV), and high-density lipoprotein (HDL) were also independently associated with hypertension in ADPKD patients.
|
31020807 |
2020 |
|
Hypertensive disease
|
0.340 |
Biomarker
|
group |
BEFREE |
These findings suggest that a selective, reversible, α<sub>1</sub>-adenoceptor-gated WNK/SPAK/OxSR1 NE-activated signaling pathway prevents dietary Na<sup>+</sup>-evoked NCC suppression, promoting the development and maintenance of salt-sensitive hypertension.
|
31608673 |
2019 |
|
Hypertensive disease
|
0.340 |
Biomarker
|
group |
BEFREE |
Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK (STE20/SPS1-related proline/alanine-rich kinase) and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension.
|
28566208 |
2017 |
|
Hypertensive disease
|
0.340 |
Therapeutic
|
group |
CTD_human |
Abnormal activation of the recently identified with-no-lysine kinase (WNK)-oxidative stress-responsive kinase 1 (OSR1)/STE20/SPS1-related proline/alanine-rich kinase (SPAK)-NaCl cotransporter (NCC) phosphorylation cascade results in the salt-sensitive hypertension of pseudohypoaldosteronism type II.
|
22949526 |
2012 |
|
Hypertensive disease
|
0.340 |
Biomarker
|
group |
BEFREE |
Here we tested whether STK39, OXSR1, and SLC12A3 genetically contribute to hypertension in the Han Chinese population and how the SNP to SNP or SNP to other risk factors interacts in the pathogenesis of hypertension.
|
20889219 |
2012 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
To compare the levels of NKCC1, KCC2, OXSR1, STK39, WNK1, WNK3, and WNK4 transcripts in prefrontal cortex area 9 between subjects with schizophrenia and healthy comparison subjects.
|
20819979 |
2011 |
|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
OXSR1 and WNK3 transcript expression levels were not changed in antipsychotic-exposed monkeys and were not affected by potential confounding factors in the subjects with schizophrenia.
|
20819979 |
2011 |
|
Metastatic melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease.
|
31020807 |
2020 |
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we aimed to investigate the potential role of OSR-1 in ADPKD patients.
|
31020807 |
2020 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
After being transfected with OXSR1, the apoptosis rates and expressions of B-cell lymphoma-2 (Bcl-2), down-regulated Bax and Cleaved caspase-3 (C caspase-3) indicated overexpressed OXSR1 contributed to cell apoptosis.
|
31362998 |
2019 |
|
Post-Hemorrhagic Hydrocephalus
|
0.010 |
Biomarker
|
disease |
BEFREE |
New studies reveal that CCCs along with their regulatory WNK (Kinase with no lysine (K)), and SPAK (Ste20-related proline-alanine-rich kinase)/OSR1(oxidative stress-responsive kinase-1) are essential for regulating cell volume and maintaining ionic homeostasis in the nervous system, especially roles of the WNK-SPAK-NKCC1 signaling pathway in ischemic brain injury and hypersecretion of cerebrospinal fluid in post-hemorrhagic hydrocephalus.
|
31165006 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Increased expression of proteins STAT5B, GRB2, and OXSR1 was related to a higher probability of metastasis.
|
30054970 |
2018 |
|
Essential Hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Studies of inherited conditions characterized by high or low blood pressure reveal the importance of a new signalling cascade, With no Lysine kinases (WNK) --> ste20/SPS1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase-1 (OSR1) --> Cation-Chloride Cotransporters (CCC), in regulating blood pressure and in the pathogenesis of essential hypertension.
|
18277153 |
2008 |