Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the molecular mechanisms of TL1A in UC development are poorly understood.
|
31176785 |
2019 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Protective association of TNFSF15 polymorphisms with Crohn's disease and ulcerative colitis: A meta-analysis.
|
29873318 |
2018 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association of TNFSF15 gene polymorphisms located in the promoter region, including rs6478108 (G/A -9706) and rs3810936 (G/A -15524) in Iranian patients with UC.
|
30556168 |
2018 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects.
|
26072972 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Moreover, we found individual disease risk loci: TNFSF15 and TNFα to CD and HLA-B*5201, and NFKBIL1 to UC.
|
23942620 |
2014 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The TNFSF15 gene has been associated with other inflammatory diseases affecting the colon such as medically refractory ulcerative colitis (UC), aggressive Crohn's disease (CD), and pouchitis after restorative proctocolectomy.
|
24814505 |
2014 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Focusing on TNFSF15 instead of NOD2, we set out to evaluate whether combining serologic and genetic markers could distinguish between Crohn’s disease (CD) and ulcerative colitis (UC), and whether they could be used to stratify the disease behavior of Taiwanese CD patients.
|
24783249 |
2014 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of seven single nucleotide polymorphisms (SNP) in the TNFSF15 gene with Crohn's disease (CD) and ulcerative colitis (UC) in the Indian population.
|
25501099 |
2014 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility.
|
25028192 |
2014 |
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
No correlation was found between the genotype and serum levels of IL-12p40 or TL1A in UC patients.
|
24382939 |
2013 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans.
|
21228792 |
2011 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association with TNFSF15 and pediatric UC was also reported.
|
21818367 |
2011 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
TL1A/DcR3-mediated pathways may participate in the pathogenesis of UC.
|
20675196 |
2010 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Comparison of the MR-UC subjects with healthy controls confirmed the contribution of the major histocompatibility complex to severe UC (peak association: rs17207986, P = 1.4 × 10(-16)) and provided genome-wide suggestive association at the TNFSF15 (TL1A) locus (peak association: rs11554257, P = 1.4 × 10(-6)).
|
20848476 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis by the modified genotype relative risk test (mGRR) indicated that the risk allele of TNFSF15 is dominant for CD, but is recessive for UC.
|
20367632 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk.
|
20176734 |
2010 |
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD).
|
19262684 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis.
|
19592695 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Of further interest, the haplotype frequency was in the opposite direction in our Jewish case-control panels (both CD and UC), leading us to conclude 1) that TNFSF15 is indeed an IBD susceptibility gene, and 2) the disease susceptibility is ethnic-specific.
|
17663424 |
2007 |