CDC42, cell division cycle 42, 998

N. diseases: 327; N. variants: 16
Disease: Multiple congenital anomalies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay. 26386261 2015
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. 23382385 2013
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties. 24059268 2013
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines. 22266952 2012
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. 21423166 2011
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Cdc42 in oncogenic transformation, invasion, and tumorigenesis. 21515363 2011
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR RHO GTPase signaling for axon extension: is prenylation important? 20878268 2010
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Cdc42 and vesicle trafficking in polarized cells. 20633244 2010
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways. 19700661 2009
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. 19092927 2008
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Further delineation of deletion 1p36 syndrome in 60 patients: a recognizable phenotype and common cause of developmental delay and mental retardation. 18245432 2008
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Molecular basis of dendritic arborization. 18511961 2008
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Monosomy 1p36 deletion syndrome. 17918734 2007
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR GEFs and GAPs: critical elements in the control of small G proteins. 17540168 2007
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma. 17970806 2007
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. 17050694 2006
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. 16949823 2006
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Rho GTPases, dendritic structure, and mental retardation. 15884002 2005
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. 15269155 2004
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Structural basis of the Rho GTPase signaling. 14561717 2003
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Development of a comparative genomic hybridization microarray and demonstration of its utility with 25 well-characterized 1p36 deletions. 12915473 2003
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Physical map of 1p36, placement of breakpoints in monosomy 1p36, and clinical characterization of the syndrome. 12687501 2003
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. 12195014 2002
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR Rho GTPases in cell biology. 12478284 2002
CUI: C0000772
Disease: Multiple congenital anomalies
Multiple congenital anomalies 		0.100 CausalMutation group CLINVAR The evolutionary history of effectors downstream of Cdc42 and Rac. 11864373 2002