|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
<i>SNAI1</i> mRNA levels strongly correlated with the expression of CCA markers, including SOX9, CK19, and EPCAM, but not with EMT markers such as E-CADHERIN and ZO-1, in human HCC samples.
|
31383647 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, our study presents the regulation mechanism of miR-101/ZNF217/CDH1 axis for the first time and provides new evidences of ZNF217 as a potential therapeutic target for HCC patients.
|
30898548 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The level of TRERNA1 was positively correlated with tumour metastasis and was negatively correlated with the expression of CDH1 in HCC tissues.
|
31012192 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, the upregulation of HDAC6 inhibited the epithelial-to-mesenchymal transition in HCC by increasing the E-cadherin protein levels and decreasing the N-cadherin, vimentin and matrix metalloproteinase-9 protein levels.
|
30546442 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
|
29862272 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These data clearly show that ARHGAP9/FOXJ2 inhibit cell migration and invasion during HCC development via inducing the transcription of CDH1.
|
30206221 |
2018 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
E-cadherin (CDH1) hypermethylation was observed to be significantly higher in HCC than in benign, adjacent, or normal samples.
|
28422868 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Aberrant sera DNA methylation of CDH1, DNMT3b and ESR1 gene promoters could be a biomarker in the early diagnosis of HBV-related HCC.
|
26660680 |
2016 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PPARA and CDH1 mRNA levels were decreased in HCC relative to controls and were inversely correlated with miR-9 levels.
|
26206264 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, ARID1A and E-cadherin (CDH1) expression were found to be regulated in a coordinated fashion in HCC samples.
|
25975202 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, our results show that MTBP and E-cadherin protein expression are inversely correlated in primary HCC tissues.
|
26280083 |
2015 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Time course analysis of invasion/metastasis gene expressions (MMP2, MMP7, MMP9, CD44, SPP1, CXCR4, CXCL12, and CDH1) showed remarkable, dynamic alterations during the invasion process of HCC.
|
24614035 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Linear regression analysis revealed a positive correlation between the expression of miR-148a and the mRNA level of E-cadherin gene in human HCC tissues.
|
24013226 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, KLF8, FAK, MMP‑9 and E‑cadherin protein expression levels were examined by western blot analysis in 5 portal vein cancer emboli and corresponding HCC tissues.
|
23670717 |
2013 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the up-regulation of EZH2, CTNNB1 and the down-regulation of CDH1 in HCC patients correlated with early recurrent disease and can be an independent predictor of poor survival.
|
22962603 |
2012 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we showed that CDH1 promoter was hypermethylated in drug resistance of a doxorubicin-induced multidrug resistant hepatocellular carcinoma cell line R-HepG2.
|
22634315 |
2012 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for other confounders, results show that individuals with the CDH1-347G/GA or GA/GA polymorphic genotypes had a significantly higher risk of developing HCC than those with the wild-type (G/G) genotype (adjusted odds ratio = 2.477; 95%CI: 1.421-4.319).
|
21462191 |
2011 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In contrast to common HCC the APC and CDH1 (E-cadherin) genes were found devoid of any DNA methylation in FLC, whereas the GSTπ1 gene showed comparable DNA methylation in tumor and surrounding tissue at a moderate level.
|
21060828 |
2010 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression.
|
20625840 |
2010 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
ROS-induced stress, E-cadherin expression, Snail expression, and E-cadherin promoter methylation were confirmed in HCC tissues by immunoblot, immunohistochemistry, and methyl-specific polymerase chain reaction analyses.
|
18801366 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We retrospectively analyzed CpG island hypermethylation of the p14, p15, p16, GSTP1, integrin alpha4, SYK, and CDH1 genes in fresh-frozen tissues from 265 patients with hepatocellular carcinoma using the methylation-specific PCR.
|
18723830 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Expression of E- and N-cadherin and clinicopathology in hepatocellular carcinoma.
|
18801083 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma.
|
18842495 |
2008 |
|
Liver carcinoma
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.
|
18049164 |
2007 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats.
|
17295234 |
2007 |