|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.
|
31077828 |
2020 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We used a Markov model of HDGC progression associated with pathogenic variants in CDH1 to simulate outcomes of hypothetical cohorts with different ages at time of PTG (ages 20-79 years).
|
31220641 |
2020 |
|
Malignant neoplasm of breast
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer.
|
30616060 |
2019 |
|
Malignant neoplasm of breast
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer.
|
30954555 |
2019 |
|
Malignant neoplasm of breast
|
0.800 |
Biomarker
|
disease |
BEFREE |
Depleting Cdh1 accelerates breast cancer cell proliferation and cooperates with PTEN loss to promote breast tumor progression in mice.
|
31420536 |
2019 |
|
Malignant neoplasm of breast
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Germline DNA from 1054 BRCA-mutation-negative Hispanic women with hereditary BC (BC diagnosed at age <51 years, bilateral BC, breast and ovarian cancer, or BC diagnosed at ages 51-70 years with ≥2 first-degree or second-degree relatives who had BC diagnosed at age <70 years), 312 local controls, and 887 multiethnic cohort controls was sequenced and analyzed for 12 known and suspected, high-penetrance and moderate-penetrance cancer susceptibility genes (ataxia telangiectasia mutated [ATM], breast cancer 1 interacting protein C-terminal helicase 1 [BRIP1], cadherin 1 [CDH1], checkpoint kinase 2 [CHEK2], nibrin [NBN], neurofibromatosis type 1 [NF1], partner and localizer of BRCA2 [PALB2], phosphatase and tensin homolog [PTEN], RAD51 paralog 3 [RAD51C], RAD51D, serine/threonine kinase 11 [STK11], and TP53).
|
31206626 |
2019 |
|
Malignant neoplasm of breast
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
We generated a breast cancer cell model to study E-cadherin-independent effects of EP300 by over-expression of EP300 in HS578T cells which have E-cadherin promoter hypermethylated.
|
30862505 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer.
|
30168144 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001).
|
30801717 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The cumulative incidence of gastric cancer for individuals with pathogenic variants in CDH1 is significantly lower than previously described.
|
31246251 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer.
|
30642281 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients.
|
30989488 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC.
|
30963578 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori.
|
29589180 |
2019 |
|
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Pathogenic germline CDH1 mutations are causative of hereditary diffuse gastric cancer, a cancer predisposition syndrome primarily characterised by an extreme lifetime risk of developing diffuse gastric cancer.
|
29589180 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer.
|
30066183 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Review of the literature revealed a significant enrichment of CDH1 mutations within the EC domains in CLP/HDGC families (Fisher's exact test, p = 0.007) in comparison to CDH1 mutations associated with HDGC only.
|
30306390 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Is prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer?
|
30466290 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC).
|
30542785 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC).
|
30745422 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This is especially detrimental in syndromes such as hereditary diffuse gastric cancer due to a CDH1 germline mutation, for which lifesaving prevention is possible.
|
31109593 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Gastric cancer standardized incidence ratio estimates relative to Surveillance, Epidemiology, and End Results (SEER) Program incidence for pathogenic CDH1 variants from families ascertained without regard to HDGC criteria.
|
31246251 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to determine associations between CDH1 germline variant status and clinical phenotypes of HDGC.
|
30745422 |
2019 |
|
Hereditary Diffuse Gastric Cancer
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
Novel Variants and Copy Number Variation in CDH1 Gene in Iranian Patients with Sporadic Diffuse Gastric Cancer.
|
29577179 |
2019 |