TPH1, tryptophan hydroxylase 1, 7166

N. diseases: 127; N. variants: 11
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.040 1.000 4 2011 2019
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		Mental Disorders 0.020 1.000 2 2012 2012
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		Mental Disorders 0.020 1.000 2 2012 2019
dbSNP: rs211105
rs211105 		1.000 11 18033757 intron variant T/G snv 0.19
CUI: C0011991
Disease: Diarrhea
Diarrhea 		Pathological Conditions, Signs and Symptoms 0.020 1.000 2 2015 2018
dbSNP: rs10488682
rs10488682 		1.000 0.160 11 18040935 5 prime UTR variant T/A snv 0.19
CUI: C0039585
Disease: Androgen-Insensitivity Syndrome
Androgen-Insensitivity Syndrome 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases 0.010 1.000 1 2008 2008
dbSNP: rs10488682
rs10488682 		1.000 0.160 11 18040935 5 prime UTR variant T/A snv 0.19
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		Nervous System Diseases; Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs1173546708
rs1173546708 		0.851 0.120 11 18040661 synonymous variant G/A snv 4.0E-06
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs1173546708
rs1173546708 		0.851 0.120 11 18040661 synonymous variant G/A snv 4.0E-06
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs1173546708
rs1173546708 		0.851 0.120 11 18040661 synonymous variant G/A snv 4.0E-06
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2008 2008
dbSNP: rs1173546708
rs1173546708 		0.851 0.120 11 18040661 synonymous variant G/A snv 4.0E-06
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs1173546708
rs1173546708 		0.851 0.120 11 18040661 synonymous variant G/A snv 4.0E-06
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs1799913
rs1799913 		0.851 0.080 11 18025708 splice region variant G/A;T snv 0.39 0.33
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2019 2019
dbSNP: rs1799913
rs1799913 		0.851 0.080 11 18025708 splice region variant G/A;T snv 0.39 0.33
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		Nervous System Diseases; Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs1799913
rs1799913 		0.851 0.080 11 18025708 splice region variant G/A;T snv 0.39 0.33
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2019 2019
dbSNP: rs1799913
rs1799913 		0.851 0.080 11 18025708 splice region variant G/A;T snv 0.39 0.33
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs1799913
rs1799913 		0.851 0.080 11 18025708 splice region variant G/A;T snv 0.39 0.33
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2008 2008
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		Digestive System Diseases 0.010 1.000 1 2014 2014
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0438696
Disease: Suicidal
Suicidal 		Behavior and Behavior Mechanisms 0.010 1.000 1 2016 2016
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0013170
Disease: Drug habituation
Drug habituation 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0013146
Disease: Drug abuse
Drug abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0004936
Disease: Mental disorders
Mental disorders 		Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs1800532
rs1800532 		0.763 0.160 11 18026269 intron variant G/T snv 0.33
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2016 2016