|
rs2617170
|
KLRC4;KLRC4-KLRK1
|
Behcet Syndrome
|
|
0.820 |
GeneticVariation |
BEFREE |
Significantly increased frequencies of the A allele as well as AA genotype of rs1800450 in MBL2 (Pc = 2.50 × 10<sup>-6</sup>, OR = 1.494; Pc = 2.24 × 10<sup>-6</sup>,OR = 2.899; respectively) and TT genotype of rs2617170 in KLRC4 (Pc = 2.53 × 10<sup>-6</sup>, OR = 1.695) and decreased frequencies of GG genotype of rs1800450 (Pc = 1.56 × 10-3, OR = 0.689) and C allele as well as CC genotype of rs2617170 (Pc = 2.05 × 10-9,OR = 0.664; Pc = 1.20 × 10-5, OR = 0.585; respectively) were observed in BD.
|
28706259 |
2017 |
|
rs2617170
|
KLRC4;KLRC4-KLRK1
|
Behcet Syndrome
|
|
0.820 |
GeneticVariation |
BEFREE |
For all 6 SNPs tested by meta-analysis (Pmeta ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] for A allele 1.29 [95% confidence interval (95% CI) 1.21-1.37], Pmeta = 2.34 × 10(-16) ; for rs7616215, OR for C allele 0.70 [95% CI 0.65-0.76], Pmeta = 1.54 × 10(-19) ; for rs17810546, OR for A allele 0.60 [95% CI 0.52-0.70], Pmeta = 6.34 × 10(-11) ; for rs2617170, OR for T allele 0.76 [95% CI 0.70-0.81], Pmeta = 2.75 × 10(-14) ; for rs13154629, OR for TT genotype 2.76 [95% CI 2.01-3.80], Pmeta = 3.57 × 10(-10) ).
|
26097239 |
2015 |
|
rs2617170
|
KLRC4;KLRC4-KLRK1
|
Behcet Syndrome
|
T |
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs2617170
|
KLRC4;KLRC4-KLRK1
|
Behcet Syndrome
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus.
|
21598106 |
2012 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, based on our study results, SLE is associated with the SNP rs2255336 of NKG2D.
|
19735685 |
2010 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Congenital cytomegalovirus infection
|
|
0.010 |
GeneticVariation |
BEFREE |
A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.
|
25861030 |
2015 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation |
BEFREE |
Using polymerase chain reaction-restriction fragment length polymorphisms, we examined the NKG2D Thr72Ala polymorphism in patients with cervical cancer (n=353) and controls (n=366) in a Polish population.
|
22480139 |
2012 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
cervical cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
Using polymerase chain reaction-restriction fragment length polymorphisms, we examined the NKG2D Thr72Ala polymorphism in patients with cervical cancer (n=353) and controls (n=366) in a Polish population.
|
22480139 |
2012 |
|
rs2255336
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Using polymerase chain reaction-restriction fragment length polymorphisms, we examined the NKG2D Thr72Ala polymorphism in patients with cervical cancer (n=353) and controls (n=366) in a Polish population.
|
22480139 |
2012 |
|
rs2617160
|
KLRC4-KLRK1;LOC101928100
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
Single marker association analysis was conducted and the SNP rs2617160 with a TT genotype in NKG2D was associated significantly with an increased risk of chronic hepatitis B (P = 0.044; OR = 1.49; 95% CI = 1.01-2.19).
|
20648603 |
2010 |
|
rs11053781
|
KLRK1;KLRC4-KLRK1;LOC101928100
|
Congenital contractural arachnodactyly
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the NKG2D SNPs were associated with an increased risk of CCA: rs11053781 [odds ratio (OR) = 2.08, 95% confidence interval (CI) = 1.31-3.29, corrected P (P(c)) = 0.011] and rs2617167 (OR = 2.32, 95% CI = 1.47-3.66, P(c) = 0.0020).
|
18023027 |
2008 |
|
rs2617167
|
KLRC4-KLRK1
|
Congenital contractural arachnodactyly
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the NKG2D SNPs were associated with an increased risk of CCA: rs11053781 [odds ratio (OR) = 2.08, 95% confidence interval (CI) = 1.31-3.29, corrected P (P(c)) = 0.011] and rs2617167 (OR = 2.32, 95% CI = 1.47-3.66, P(c) = 0.0020).
|
18023027 |
2008 |