DisGeNET - a database of gene-disease associations

FAM3C, FAM3 metabolism regulating signaling molecule C, 10447

N. diseases: 32; N. variants: 13

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs917726

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

29304378

2018

dbSNP:

rs917727

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.

28743860

2017

dbSNP:

rs917727

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0424678
Disease:

Lean body mass

0.700

GeneticVariation

GWASCAT

Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.

28743860

2017

dbSNP:

rs371847000

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

24249740

2014

dbSNP:

rs4727923

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

24249740

2014

dbSNP:

rs529951808

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

24249740

2014

dbSNP:

rs58750532

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

24249740

2014

dbSNP:

rs7776725

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

24945404

2014

dbSNP:

rs2254595

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs2536180

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs2536182

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs3801382

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs4727924

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs718766

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs7776725

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs917726

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs917727

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0177804
Disease:

Bone Mineral Density Test

0.700

GeneticVariation

GWASDB

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs917727

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

22792070

2012

dbSNP:

rs7776725

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0005938
Disease:

Bone Density

0.700

GeneticVariation

GWASCAT

On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1.9 x 10(-10)).

19396169

2009

dbSNP:

rs7776725

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0205682
Disease:

Waist-Hip Ratio

0.700

GeneticVariation

GWASDB

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

19396169

2009

dbSNP:

rs7776725

Entrez Id:	10447
Gene Symbol:	FAM3C

FAM3C

CUI:	C0029456
Disease:

Osteoporosis

0.010

GeneticVariation

BEFREE

The rs7776725 showed consistent association with BMD at multiple clinically important skeletal sites, which highlighted the potential importance of rs7776725 or linked SNPs for risk of osteoporosis.

22159821

2012