rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
19734903
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
19136949
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
19734903
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASDB
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
20061627
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
20061627
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASDB
Genome-wide analysis of genetic loci associated with Alzheimer disease.
20460622
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Genome-wide analysis of genetic loci associated with Alzheimer disease.
20460622
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
21123754
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
21460841
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
21379329
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.
21098978
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
22005931
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
22005930
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study of Alzheimer's disease.
22832961
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05).
23573206
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Recently, the rs2075650 single nucleotide polymorphism in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene was identified as a risk factor for AMD and Alzheimer disease .
24146538
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
24755620
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3 865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
24176626
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
24770881
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
24770881
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
24788522
2014