|
rs3782089
|
ZNRD2;ZNRD2-AS1
|
Body Height
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
rs3782089
|
ZNRD2;ZNRD2-AS1
|
Height
|
T |
0.700 |
GeneticVariation |
GWASDB |
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
20881960 |
2010 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Carcinogenesis
|
|
0.020 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Carcinogenesis
|
|
0.020 |
GeneticVariation |
BEFREE |
Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
|
25583987 |
2015 |
|
rs1290923018
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation |
BEFREE |
Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma.
|
31205550 |
2019 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs750814369
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility.
|
28317869 |
2017 |
|
rs750814369
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility.
|
28317869 |
2017 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Myeloid Leukemia, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Leukemogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
|
rs750814369
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Liver carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the variant genotypes of p21 Ser31Arg and p27 C-79T were individually associated with a significantly increased risk of HCC, but no associations were observed for other variant genotypes.
|
23034899 |
2013 |
|
rs745594285
|
ZNRD2;FAM89B;ZNRD2-AS1
|
PITUITARY ADENOMA, FAMILIAL ISOLATED (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
In vitro, the K96Q change decreased p27 affinity for Grb2 but did not segregate with pituitary adenoma in the FIPA kindred.
|
22291433 |
2012 |
|
rs758434928
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.
|
22449259 |
2012 |
|
rs758434928
|
ZNRD2;FAM89B;ZNRD2-AS1
|
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.
|
22449259 |
2012 |
|
rs777803098
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Amyotrophic Lateral Sclerosis
|
|
0.010 |
GeneticVariation |
BEFREE |
G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis.
|
20561900 |
2010 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Aplasia Cutis Congenita
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we transfected nondegradable p27 mutant (T187A) and wild-type gene into A</span>CC cell line.
|
17431674 |
2007 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Agenesis of corpus callosum
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we transfected nondegradable p27 mutant (T187A) and wild-type gene into A</span>CC cell line.
|
17431674 |
2007 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27.
|
15996662 |
2005 |
|
rs1190999960
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27.
|
15996662 |
2005 |
|
rs1290923018
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Retinoblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Conversely, CLA reduced the expression of factors required for G1 to S-phase transition including cyclins D1 and E, and hyperphoshorylated retinoblastoma Rb protein.
|
14608092 |
2003 |
|
rs1290923018
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation |
BEFREE |
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.
|
12954644 |
2003 |
|
rs1290923018
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.
|
12954644 |
2003 |
|
rs1290923018
|
ZNRD2;FAM89B;ZNRD2-AS1
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Among many candidates for tumor suppressor genes, the main genetic events have been reported to center around the cyclin-dependent kinase inhibitors ((CDKIs) p15INK4A, p16INK4B, p18INK4C, p19INK4D, p21WAF1, p27KIP1, and p57KIP2), p53 and Rb genes; all of them play a major regulatory role during G1 to S transition in the cell cycle.
|
12040438 |
2002 |