|
rs2893321
|
TNFSF13B
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations of rs2893321 with susceptibility to GD and AITDs and the correlation between rs2893321 and TAb exhibit a dimorphic pattern.
|
27136204 |
2016 |
|
rs2582869
|
TNFSF13B
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, the single most significant SNPs associated with NHL were FAS rs4934436 (p-trend = 0.0024), IRF4 rs12211228 (p-trend = 0.0026), TNFSF13B rs2582869 (p-trend = 0.0055), TANK rs1921310 (p-trend = 0.0025), TNFSF7 rs16994592 (p-trend = 0.0024), and TNFRSF13C rs6002551 (p-trend = 0.0074).
|
19390683 |
2009 |
|
rs9514828
|
TNFSF13B
|
Chronic Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation |
BEFREE |
Although the obtained P-values for all 20 SNPs did not reach statistical significance for this study (α = 0.003), the high value of the global chi-squared statistic (χ(2) df = 38 = 52.65; P = 0.0586), and obtained values of odds ratio indicate that rs9514828 (BAFF), rs3803800 (APRIL) and rs4985726 (TACI) may be associated with the risk of B-CLL.
|
26268376 |
2015 |
|
rs9514828
|
TNFSF13B
|
B-CELL MALIGNANCY, LOW-GRADE
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the obtained P-values for all 20 SNPs did not reach statistical significance for this study (α = 0.003), the high value of the global chi-squared statistic (χ(2) df = 38 = 52.65; P = 0.0586), and obtained values of odds ratio indicate that rs9514828 (BAFF), rs3803800 (APRIL) and rs4985726 (TACI) may be associated with the risk of B-CLL.
|
26268376 |
2015 |
|
rs1161169998
|
TNFSF13B
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation |
BEFREE |
Conclusion p.G76S mutation on the TNFRSF13B gene is responsible for ITP, and is a genetic predisposing factor for familial or sporadic ITP.
|
28834165 |
2017 |
|
rs2893321
|
TNFSF13B
|
Myasthenia Gravis
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variations of rs2893321 in BAFF might be associated with susceptibility to MG in the Chinese Han population.
|
31666013 |
2019 |
|
rs17499386
|
TNFSF13B
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
rs9514828
|
TNFSF13B
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
High BAFF expression associated with active disease in systemic lupus erythematosus and relationship with rs9514828C>T polymorphism in TNFSF13B gene.
|
30747361 |
2019 |
|
rs16972217
|
TNFSF13B
|
Chronic graft-versus-host disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.
|
21628416 |
2011 |
|
rs7993590
|
TNFSF13B
|
Chronic graft-versus-host disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.
|
21628416 |
2011 |
|
rs12428930
|
TNFSF13B
|
Chronic graft-versus-host disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.
|
21628416 |
2011 |
|
rs2893321
|
TNFSF13B
|
Chronic graft-versus-host disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.
|
21628416 |
2011 |
|
rs9514828
|
TNFSF13B
|
T-Cell Lymphoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In multivariate Cox-regression analysis, rs3742330 proved to be an independent predictor for OS, together with the commonly used International Prognostic Index (IPI) and BAFF rs9514828, another SNP we have previously reported to be associated with TCL survival, with hazard ratios (HRs) for patient death rate of 8.956 (95% CI, 1.210 to 66.318; p = 0.032) for the GA genotype and 10.145 (95% CI, 1.371 to 75.084; p = 0.023) for the AA genotype.
|
23251602 |
2012 |
|
rs12583006
|
TNFSF13B
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
|
rs12583006
|
TNFSF13B
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
|
rs12583006
|
TNFSF13B
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
|
rs12583006
|
TNFSF13B
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
|
rs9514828
|
TNFSF13B
|
Chronic Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results point to a possible association between the rs9514828 (CT vs. CC + TT; OR = 0.74; CI 95 % = 0.57; 0.97; p = 0.022) and rs1041569 (AT vs. AA + TT; OR = 0.72; CI 95 % = 0.54; 0.95; p = 0.021) of BAFF gene and rs61756766 (CC vs. CT; OR = 2.03; CI 95 % = 1.03; 3.99; p = 0.03) of BAFF-R gene and CLL risk.
|
27468724 |
2016 |
|
rs1041569
|
TNFSF13B
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results point to a possible association between the rs9514828 (CT vs. CC + TT; OR = 0.74; CI 95 % = 0.57; 0.97; p = 0.022) and rs1041569 (AT vs. AA + TT; OR = 0.72; CI 95 % = 0.54; 0.95; p = 0.021) of BAFF gene and rs61756766 (CC vs. CT; OR = 2.03; CI 95 % = 1.03; 3.99; p = 0.03) of BAFF-R gene and CLL risk.
|
27468724 |
2016 |
|
rs9514828
|
TNFSF13B
|
Hepatitis B
|
|
0.020 |
GeneticVariation |
BEFREE |
Regarding BAFF polymorphisms, the frequency of rs9514828 CT + TT genotypes was higher distributed in patients with chronic HBV infection compared with healthy controls (58.0% vs. 46.0%, P = 0.029).
|
30660167 |
2019 |
|
rs374039502
|
TNFSF13B
|
Giant Cell Arteritis
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, combined analysis of the different sets evidenced a lack of association of the rs374039502 variant with GCA (P = 0.421; OR (95% CI) = 0.92 (0.75-1.13)) and SSc (P = 0.500; OR (95% CI) = 1.05 (0.91-1.22)).
|
30586461 |
2018 |
|
rs374039502
|
TNFSF13B
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, combined analysis of the different sets evidenced a lack of association of the rs374039502 variant with GCA (P = 0.421; OR (95% CI) = 0.92 (0.75-1.13)) and SSc (P = 0.500; OR (95% CI) = 1.05 (0.91-1.22)).
|
30586461 |
2018 |
|
rs200748895
|
TNFSF13B
|
White Blood Cell Count procedure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs200748895
|
TNFSF13B
|
Platelet Count measurement
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs374039502
|
TNFSF13B
|
Platelet Component Distribution Width Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |