|
rs7667050
|
PPARGC1A
|
Glomerular Filtration Rate
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
rs8192678
|
PPARGC1A
|
Non-alcoholic Fatty Liver Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
A common polymorphism in this gene (rs8192678, encoding Gly482Ser) has been associated with NAFLD.
|
27658772 |
2017 |
|
rs3736265
|
PPARGC1A
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |
|
rs3774923
|
PPARGC1A
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
A DNA coding variant (rs3736265) and a 3'UTR-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exact P = 0.003, both SNPs).
|
23335958 |
2013 |
|
rs12650199
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs16874921
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs2970855
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs4619879
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs4697046
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs6448226
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs7679405
|
PPARGC1A
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
rs34751092
|
PPARGC1A
|
Regular astigmatism - corneal
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study of corneal astigmatism: The CREAM Consortium.
|
29422769 |
2018 |
|
rs8192678
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
rs8192678
|
PPARGC1A
|
Obesity
|
|
0.080 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
|
rs8192678
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes.
|
11793024 |
2001 |
|
rs8192678
|
PPARGC1A
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for age, sex, body mass index, and antihypertensive medication, G482S and +2962A/G polymorphisms were significantly associated with systolic blood pressures in hypertension patients with medication use (p = 0.023 and 0.022 for G482S and +2962A/G respectively) but not in all participants, normotensives, and patients with no medication use.
|
17971240 |
2007 |
|
rs17590046
|
PPARGC1A
|
Essential Tremor
|
|
0.730 |
GeneticVariation |
BEFREE |
After Bonferroni correction two markers, one (rs10937625) located in the serine/threonine kinase STK32B and one (rs17590046) in the transcriptional coactivator PPARGC1A were associated with essential tremor.
|
27797806 |
2016 |
|
rs4235308
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308</span> (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs7656250
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification with sex, in Haitian Americans, both rs4235308 (OR = 0.38, P = 0.026) and rs7656250 (OR = 0.23, P = 0.006) showed protective association with T2D in females whereas in African American males rs7656250 had statistically significant protective effect on T2D (OR = 0.37, P = 0.043).
|
25977930 |
2015 |
|
rs8192678
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
|
30393491 |
2018 |
|
rs8192678
|
PPARGC1A
|
Non-alcoholic Fatty Liver Disease
|
|
0.030 |
GeneticVariation |
BEFREE |
Although clinical evidence suggests that Gly482Ser polymorphism of PGC-1α is associated with an increased incidence of nonalcoholic fatty liver disease, a direct role for Gly482Ser mutation in altering PGC-1α actions on hepatocyte fat deposition remains to be explored.
|
23602251 |
2013 |
|
rs8192678
|
PPARGC1A
|
Hypertensive disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the 3 polymorphic sites, genotype distributions associated with Gly482Ser differed by hypertension status in men (P=0.0038), but not in women.
|
12574109 |
2003 |
|
rs3774921
|
PPARGC1A
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated polymorphisms, heterozygous carriers of rs3774921 in PPARGC1A showed a higher risk of colorectal cancer (OR [95% CI] = 1.26 [1.02-1.55] for TC vs. TT).
|
28051997 |
2017 |
|
rs3774921
|
PPARGC1A
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated polymorphisms, heterozygous carriers of rs3774921 in PPARGC1A showed a higher risk of colorectal cancer (OR [95% CI] = 1.26 [1.02-1.55] for TC vs. TT).
|
28051997 |
2017 |
|
rs2970870
|
PPARGC1A
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented.
|
28453464 |
2017 |