|
rs2267735
|
ADCYAP1R1
|
Post-Traumatic Stress Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that the C allele of rs2267735 conferred significant risk for PTSD in the combined sex data, OR = 1.210, 95% CI [1.007, 1.454], p = .042, and in the subsample of women and girls, OR = 1.328, 95% CI [1.026, 1.719], p = .031; but not in the subsample of men and boys, OR = 0.964, 95% CI [0.733, 1.269], p = .796.
|
28746747 |
2017 |
|
rs2267735
|
ADCYAP1R1
|
Post-Traumatic Stress Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
Inhibition of E2/ERα binding to the ERE containing the rs2267735 risk allele results in reduced expression of ADCYAP1R1, diminishing estrogen regulation as an adaptive stress response and increasing risk for PTSD.
|
27959335 |
2016 |
|
rs2267735
|
ADCYAP1R1
|
Post-Traumatic Stress Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
Association with a single nucleotide polymorphism (rs2267735) in the gene ADCYAP1R1 encoding the type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been reported with PTSD in female patients.
|
25680674 |
2015 |
|
rs2267735
|
ADCYAP1R1
|
Post-Traumatic Stress Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
The results indicated that although the rs2267735 'CC' genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's emotional numbing symptoms in women.
|
23394710 |
2013 |
|
rs2267735
|
ADCYAP1R1
|
Post-Traumatic Stress Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
(2011); Nature 470:492-497] demonstrated that a variant, rs2267735, in the gene encoding PAC1 (ADCYAP1R1) is associated with post-traumatic stress disorder (PTSD) in a primarily African-American cohort of highly traumatized females.
|
23505260 |
2013 |
|
rs12668955
|
ADCYAP1R1
|
Cluster Headache
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion rs12668955 and rs1006417 do not impact the risk of developing cluster headache in the Swedish population.
|
28831700 |
2017 |
|
rs10081254
|
ADCYAP1R1
|
Sudden infant death syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The intron 3 variant, A/G: rs758995 (variant 'h'), and the intron 6 variant, C/T: rs10081254 (variant 'n'), were significantly associated with SIDS in Caucasians and African Americans, respectively (p < 0.05).
|
23981011 |
2013 |
|
rs2267734
|
ADCYAP1R1
|
Sudden infant death syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Also associated with SIDS were interactions between the variants rs2302475 (variant 'i') in PAC1 and rs8192597 and rs2856966 in PACAP among Caucasians (p < 0.02) and rs2267734 (variant 'q') in PAC1 and rs1893154 in PACAP among African Americans (p < 0.01).
|
23981011 |
2013 |
|
rs2267735
|
ADCYAP1R1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allele of single nucleotide polymorphism rs2267735 was significantly associated with increased odds of asthma (adjusted odds ratio, 1.3; 95% confidence interval, 1.02-1.67; P = 0.03).
|
23328528 |
2013 |
|
rs2302475
|
ADCYAP1R1
|
Sudden infant death syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Also associated with SIDS were interactions between the variants rs2302475 (variant 'i') in PAC1 and rs8192597 and rs2856966 in PACAP among Caucasians (p < 0.02) and rs2267734 (variant 'q') in PAC1 and rs1893154 in PACAP among African Americans (p < 0.01).
|
23981011 |
2013 |
|
rs758995
|
ADCYAP1R1
|
Sudden infant death syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The intron 3 variant, A/G: rs758995 (variant 'h'), and the intron 6 variant, C/T: rs10081254 (variant 'n'), were significantly associated with SIDS in Caucasians and African Americans, respectively (p < 0.05).
|
23981011 |
2013 |