TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: MAJOR AFFECTIVE DISORDER 4 ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1386482
rs1386482
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1970943
Disease:
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006). 19352219 2009
dbSNP: rs1386483
rs1386483
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1970943
Disease:
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD. 19352219 2009
dbSNP: rs1386486
rs1386486
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1970943
Disease:
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE SNPs rs1386482 and rs1386486, which are in very strong linkage disequilibrium, were associated with BPAD (P=0.006). 19352219 2009
dbSNP: rs4290270
rs4290270
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1970943
Disease:
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE The associated SNPs are in perfect linkage disequilibrium with SNPs previously associated with BPAD (rs4290270) and impulsivity (rs1386483), a core trait of BPAD. 19352219 2009
dbSNP: rs17110563
rs17110563
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1970943
Disease:
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD. 17905754 2008