Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic 		0.900 GeneticVariation BEFREE In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic 		C 0.900 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic 		0.900 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454 2018
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic 		0.900 GeneticVariation GWASDB In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 × 10(-21), OR = 2.35). 23456092 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.840 GeneticVariation BEFREE Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk. 27450204 2016
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.840 GeneticVariation GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657 2010
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.840 GeneticVariation BEFREE In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population. 22930414 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.840 GeneticVariation BEFREE The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer. 24093763 2014
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		G 0.840 GeneticVariation GWASCAT Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717 2009
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.840 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924 2010
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001948
Disease:
Alcohol consumption 		T 0.800 GeneticVariation GWASCAT We also observed a genome-wide significant association in non-Hispanic whites between the previously reported SNP rs1229984 in ADH1B and both alcohol consumption phenotypes (OR=0.79, P=2.47 × 10<sup>-20</sup> for drinker status and beta=-0.19, P=1.91 × 10<sup>-35</sup> for drinks/week), which replicated in Hispanic/Latinos (OR=0.72, P=4.35 × 10<sup>-7</sup> and beta=-0.21, P=2.58 × 10<sup>-6</sup>, respectively). 28485404 2017
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001948
Disease:
Alcohol consumption 		0.800 GeneticVariation GWASCAT A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. 23743675 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0018671
Disease:
Head and Neck Neoplasms 		T 0.800 GeneticVariation GWASCAT A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 21437268 2011
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0018671
Disease:
Head and Neck Neoplasms 		T 0.800 GeneticVariation GWASDB A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 21437268 2011
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0001948
Disease:
Alcohol consumption 		0.800 GeneticVariation GWASDB A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. 23743675 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		G 0.750 GeneticVariation GWASDB Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717 2009
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.750 GeneticVariation BEFREE In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population. 22930414 2013
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.750 GeneticVariation BEFREE Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk. 27450204 2016
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.750 GeneticVariation BEFREE The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer. 24093763 2014
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.750 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924 2010
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.750 GeneticVariation BEFREE ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively. 25770642 2015
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.710 GeneticVariation BEFREE To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. 25011450 2014
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.710 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C0153389
Disease:
malignant neoplasm of lateral wall of oropharynx 		G 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. 27749845 2016
dbSNP: rs1229984
rs1229984
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
CUI: C2931822
Disease:
Nasopharyngeal carcinoma 		0.700 GeneticVariation GWASDB A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. 20512145 2010