DisGeNET - a database of gene-disease associations

ADH1C, alcohol dehydrogenase 1C (class I), gamma polypeptide, 126

N. diseases: 146; N. variants: 18

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1789924

Entrez Id:	126
Gene Symbol:	ADH1C

ADH1C

CUI:	C0018671
Disease:

Head and Neck Neoplasms

0.800

GeneticVariation

GWASCAT

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

21437268

2011

dbSNP:

rs1789924

Entrez Id:	126
Gene Symbol:	ADH1C

ADH1C

CUI:	C0018671
Disease:

Head and Neck Neoplasms

0.800

GeneticVariation

GWASDB

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

21437268

2011

dbSNP:

rs1614972

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.710

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs1614972

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.710

GeneticVariation

BEFREE

Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.

23516558

2013

dbSNP:

rs1612735

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs1612735

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs1612735

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

30940813

2019

dbSNP:

rs62307295

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C1445957
Disease:

Serum total cholesterol measurement

0.700

GeneticVariation

GWASCAT

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

30275531

2018

dbSNP:

rs1789924

Entrez Id:	126
Gene Symbol:	ADH1C

ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.700

GeneticVariation

GWASCAT

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.

28714907

2017

dbSNP:

rs1789924

Entrez Id:	126
Gene Symbol:	ADH1C

ADH1C

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.

28714907

2017

dbSNP:

rs1789924

Entrez Id:	126
Gene Symbol:	ADH1C

ADH1C

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.

28714907

2017

dbSNP:

rs12639833

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs12639833

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs12639833

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs1614972

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs1614972

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs2241894

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236664
Disease:

Alcohol-Related Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs2241894

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0236970
Disease:

Alcohol-Induced Disorders

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs2241894

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.700

GeneticVariation

GWASCAT

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

24166409

2014

dbSNP:

rs283413

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C1838867
Disease:

PARKINSON DISEASE, MITOCHONDRIAL (disorder)

0.700

SusceptibilityMutation

CLINVAR

dbSNP:

rs698

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.050

GeneticVariation

BEFREE

Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.

28610454

2018

dbSNP:

rs698

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.050

GeneticVariation

BEFREE

The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms.

27172571

2016

dbSNP:

rs698

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.050

GeneticVariation

BEFREE

To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.

25372623

2015

dbSNP:

rs698

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.050

GeneticVariation

BEFREE

No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected.

22325912

2012

dbSNP:

rs698

Entrez Id:	125;126
Gene Symbol:	ADH1B;ADH1C

ADH1B;ADH1C

CUI:	C0001973
Disease:

Alcoholic Intoxication, Chronic

0.050

GeneticVariation

BEFREE

The results showed strong evidence of association between ADH1C Ile350Val (rs698, formerly ADH1C *1/*2) and alcohol dependence (AD) and abuse in the combined studies.

22476623

2012