LACC1, laccase domain containing 1, 144811

N. diseases: 35; N. variants: 2
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		0.820 GeneticVariation BEFREE We also confirmed the association between missense variant rs3764147 (c.760A>G [p.Ile254Val]) in the GWAS hit LACC1 (formerly C13orf31) and leprosy (p = 6.11 × 10<sup>-18</sup>, OR = 1.605). 29706348 2018
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		0.820 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		0.820 GeneticVariation GWASDB Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. 22019778 2011
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		G 0.820 GeneticVariation GWASDB Genomewide association study of leprosy. 20018961 2009
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		G 0.820 GeneticVariation GWASCAT Genomewide association study of leprosy. 20018961 2009
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		0.810 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		0.810 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASDB Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASCAT Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASCAT Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		G 0.810 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.700 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		G 0.700 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0026769
Disease:
Multiple Sclerosis 		0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364 2011
dbSNP: rs730880295
rs730880295
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C1858558
Disease:
Rheumatoid Arthritis, Systemic Juvenile 		0.700 GeneticVariation UNIPROT
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C1384600
Disease:
Systemic onset juvenile chronic arthritis 		0.010 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs730880295
rs730880295
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0023343
Disease:
Leprosy 		0.010 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs730880295
rs730880295
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C1384600
Disease:
Systemic onset juvenile chronic arthritis 		0.010 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs730880295
rs730880295
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0010346
Disease:
Crohn Disease 		0.010 GeneticVariation BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
dbSNP: rs3764147
rs3764147
Entrez Id: 144811
Gene Symbol: LACC1
LACC1
CUI: C0009324
Disease:
Ulcerative Colitis 		0.010 GeneticVariation BEFREE SNP-SNP interaction analyses showed that the combination of SNPs in the PTPN22 (rs2476601) and C13orf31 (rs3764147) genes increase the risk for UC. 23974994 2013