DIO2, iodothyronine deiodinase 2, 1734

N. diseases: 79; N. variants: 10
Disease: Hypertensive disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs225014
rs225014
Entrez Id: 1734
Gene Symbol: DIO2
DIO2
CUI: C0020538
Disease:
Hypertensive disease 		0.020 GeneticVariation BEFREE There are a number of reports describing the association between the Thr92Ala-DIO2 polymorphism and clinical syndromes that include hypertension, type 2 diabetes, mental disorders, lung injury, bone turnover, and autoimmune thyroid disease; but these associations have not been reproduced in all population studies. 30063552 2018
dbSNP: rs225014
rs225014
Entrez Id: 1734
Gene Symbol: DIO2
DIO2
CUI: C0020538
Disease:
Hypertensive disease 		0.020 GeneticVariation BEFREE The present study evaluated whether a type 2 iodothyronine deiodinase nonsynonymous polymorphism, threonine 92 to alanine (Thr92Ala), is a determinant of hypertension susceptibility. 17224473 2007
dbSNP: rs225015
rs225015
Entrez Id: 1734
Gene Symbol: DIO2
DIO2
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE In the AMI cohort, associations between: DIO1 rs12095080 and hypertension; DIO2 rs225015 and diabetes mellitus; and the OATP1C1 rs974453 genotype, and AMI type were established. 29641285 2018