E2F2, E2F transcription factor 2, 1870

N. diseases: 75; N. variants: 13
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0200638
Disease:
Eosinophil count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2811972
rs2811972
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2811974
rs2811974
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6684709
rs6684709
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		A 0.700 GeneticVariation GWASCAT Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. 28957414 2017
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0427460
Disease:
Red cell distribution width determination 		A 0.700 GeneticVariation GWASCAT Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. 28957414 2017
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0427460
Disease:
Red cell distribution width determination 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs2075995
rs2075995
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0200638
Disease:
Eosinophil count procedure 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3218192
rs3218192
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0200641
Disease:
Blood basophil count (lab test) 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3218192
rs3218192
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0200638
Disease:
Eosinophil count procedure 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs35229050
rs35229050
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0524587
Disease:
Mean Corpuscular Volume (result) 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs35229050
rs35229050
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs6684709
rs6684709
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C0023508
Disease:
White Blood Cell Count procedure 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs2742976
rs2742976
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0280313
Disease:
Squamous cell carcinoma of oropharynx 		0.010 GeneticVariation BEFREE Compared with patients with variant genotypes of E2F2-rs2742976 and E2F2-rs3218123, patients with common homozygous genotypes had better disease-free survival (both log-rank, P < 0.001) and lower SCCOP recurrence risk (HR, 0.4, 95% CI, 0.3-0.6 and HR, 0.3, 95% CI, 0.2-0.5, respectively) after multivariable adjustment. 27864908 2017
dbSNP: rs3218123
rs3218123
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0280313
Disease:
Squamous cell carcinoma of oropharynx 		0.010 GeneticVariation BEFREE Compared with patients with variant genotypes of E2F2-rs2742976 and E2F2-rs3218123, patients with common homozygous genotypes had better disease-free survival (both log-rank, P < 0.001) and lower SCCOP recurrence risk (HR, 0.4, 95% CI, 0.3-0.6 and HR, 0.3, 95% CI, 0.2-0.5, respectively) after multivariable adjustment. 27864908 2017
dbSNP: rs2742976
rs2742976
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C0020179
Disease:
Huntington Disease 		0.010 GeneticVariation BEFREE Furthermore, rs2742976 T allele patient carriers exhibited significantly lower lymphocyte E2F2 gene expression, suggesting a possible implication of E2F2-dependent transcriptional activity in HD pathogenesis. 26148071 2015
dbSNP: rs2742976
rs2742976
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012
dbSNP: rs3218123
rs3218123
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012
dbSNP: rs3218148
rs3218148
Entrez Id: 1870;101928163
Gene Symbol: E2F2;LOC101928163
E2F2;LOC101928163
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012
dbSNP: rs3218203
rs3218203
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012
dbSNP: rs3218211
rs3218211
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012
dbSNP: rs6667575
rs6667575
Entrez Id: 1870
Gene Symbol: E2F2
E2F2
CUI: C1168401
Disease:
Squamous cell carcinoma of the head and neck 		0.010 GeneticVariation BEFREE Although none of the selected SNPs alone was significantly associated with risk of SCCHN, there was a statistically significantly increased risk of SCCHN associated with the combined risk genotypes (i.e., rs3213182 AA, rs3213183 GG, rs3213180 GG, rs321318121 GG, rs2742976 GT+TT, rs6667575 GA+AA, rs3218203 CC, rs3218148 AA, rs3218211 CC, and rs3218123 GT+TT). 22344756 2012