|
rs7980288
|
A2M;KLRG1
|
Adolescent idiopathic scoliosis
|
|
0.700 |
GeneticVariation |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
rs7980288
|
A2M;KLRG1
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
|
0.700 |
GeneticVariation |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
rs669
|
A2M;KLRG1
|
ALZHEIMER DISEASE, SUSCEPTIBILITY TO
|
C |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
The meta-analysis suggests that there is no enough evidence for associations of A2M gene polymorphisms (5 bp I/D, Ile1000Val) with AD risk at present, even after stratification by ethnicity and APOE ε4 with genotypes of polymorphism sites.
|
24756728 |
2014 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
Through combination-analysis of the data about the A2M-I/D and the A2M-Ile1000Val variants, the A2M gene was suggested to be associated with Alzheimer's disease.
|
15931081 |
2005 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
Allelic frequencies with the I1000V polymorphism in the gene were 7.4 and 6.8% in the control and AD groups, respectively.
|
10936700 |
2000 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
In contrast, there was no relationship between the alpha2m Val1000Ile polymorphism and Alzheimer's disease in these families.
|
10688047 |
2000 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer's disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of alpha(2)-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and alpha(1)-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese.
|
11099722 |
2000 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64).
|
11058789 |
2000 |
|
rs669
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
|
10203250 |
1999 |
|
rs3832852
|
A2M;KLRG1
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The result suggested that rs3832852 polymorphisms were not associated with PD in all genetic models.
|
25495992 |
2016 |
|
rs669
|
A2M;KLRG1
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in PD.
|
25495992 |
2016 |
|
rs3832852
|
A2M;KLRG1
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Accumulating studies have evaluated the association of Alpha-2-Macroglobulin gene (A2M) 5 bp insertion/deletion (5 bp I/D, rs3832852) and Ile1000Val (rs669) polymorphisms with Alzheimer's disease (AD) risk, but the results remain inconclusive.
|
24756728 |
2014 |
|
rs669
|
A2M;KLRG1
|
Argyrophilic grain disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the present study shows that the valine to isoleucine (Val1000Ile) polymorphism of A2M is linked with AGD (P=0.03).
|
12175343 |
2002 |
|
rs669
|
A2M;KLRG1
|
Mental disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64).
|
11058789 |
2000 |
|
rs669
|
A2M;KLRG1
|
Mild cognitive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64).
|
11058789 |
2000 |
|
rs669
|
A2M;KLRG1
|
Abnormal behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively recruited gerontopsychiatric patients, diagnosed as: Alzheimer's disease (N=88), mild cognitive impairment (N=32), subjective cognitive complaints (N=54) and depression/other psychiatric disorders (N=64).
|
11058789 |
2000 |