F2, coagulation factor II, thrombin, 2147

N. diseases: 61; N. variants: 24
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0038454
Disease:
Cerebrovascular accident 		A 0.810 GeneticVariation GWASCAT Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. 26908601 2016
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0038454
Disease:
Cerebrovascular accident 		A 0.810 SusceptibilityMutation CLINVAR Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis. 27031503 2016
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0038454
Disease:
Cerebrovascular accident 		A 0.810 SusceptibilityMutation CLINVAR The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. 19652888 2009
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0038454
Disease:
Cerebrovascular accident 		A 0.810 SusceptibilityMutation CLINVAR The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. 15059842 2004
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0038454
Disease:
Cerebrovascular accident 		A 0.810 SusceptibilityMutation CLINVAR Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia. 11443298 2001
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASDB Biological, clinical and population relevance of 95 loci for blood lipids. 20686565 2010
dbSNP: rs3136441
rs3136441
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT Biological, clinical and population relevance of 95 loci for blood lipids. 20686565 2010
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		0.730 GeneticVariation GWASCAT Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. 31420334 2019
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		A 0.730 GeneticVariation GWASCAT Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. 31676865 2019
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		A 0.730 GeneticVariation GWASCAT Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. 28373160 2017
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		A 0.730 GeneticVariation GWASCAT Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. 26908601 2016
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		A 0.730 GeneticVariation GWASCAT Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. 25772935 2015
dbSNP: rs1799963
rs1799963
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0948008
Disease:
Ischemic stroke 		A 0.720 GeneticVariation GWASCAT Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. 26908601 2016
dbSNP: rs3136516
rs3136516
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		G 0.700 GeneticVariation GWASCAT Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. 31420334 2019
dbSNP: rs776618390
rs776618390
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C4021097
Disease:
Reduced prothrombin activity 		C 0.700 GeneticVariation CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
dbSNP: rs5896
rs5896
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0040420
Disease:
Tonometry 		C 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify new loci influencing intraocular pressure. 29617998 2018
dbSNP: rs5899
rs5899
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs75185853
rs75185853
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs3136516
rs3136516
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C1861172
Disease:
Venous Thromboembolism 		G 0.700 GeneticVariation GWASCAT Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. 28373160 2017
dbSNP: rs61884307
rs61884307
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0036341
Disease:
Schizophrenia 		C 0.700 GeneticVariation GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
dbSNP: rs61884307
rs61884307
Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C0008074
Disease:
Child Development Disorders, Pervasive 		C 0.700 GeneticVariation GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017