FGA, fibrinogen alpha chain, 2243

N. diseases: 118; N. variants: 20
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0337428
Disease:
Fibrinogen assay 		C 0.800 GeneticVariation GWASDB Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease. 21757653 2011
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0337428
Disease:
Fibrinogen assay 		C 0.800 GeneticVariation GWASCAT Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease. 21757653 2011
dbSNP: rs121909612
rs121909612
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0268389
Disease:
Amyloidosis, familial visceral 		0.800 GeneticVariation UNIPROT Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. 8097946 1993
dbSNP: rs78506343
rs78506343
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0268389
Disease:
Amyloidosis, familial visceral 		0.800 GeneticVariation UNIPROT Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. 8097946 1993
dbSNP: rs121909612
rs121909612
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0268389
Disease:
Amyloidosis, familial visceral 		A 0.800 CausalMutation CLINVAR
dbSNP: rs78506343
rs78506343
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0268389
Disease:
Amyloidosis, familial visceral 		A 0.800 CausalMutation CLINVAR
dbSNP: rs121909607
rs121909607
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1260903
Disease:
Dysfibrinogenemia 		0.710 GeneticVariation BEFREE Gene analysis confirmed inherited dysfibrinogenemia, with a heterozygous mutation in FGA (Aα Arg16His) in the patient and his mother. 23962069 2013
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1861172
Disease:
Venous Thromboembolism 		0.710 GeneticVariation GWASDB Genetics of venous thrombosis: insights from a new genome wide association study. 21980494 2011
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1861172
Disease:
Venous Thromboembolism 		0.710 GeneticVariation BEFREE To determine the genetic risk factors for venous thromboembolism (VTE), this study examined 14 genetic variants from 10 hemostatic genes in 186 Taiwanese VTE patients and the same number of matched controls, which demonstrated FGA (encoding alpha fibrinogen) Thr312Ala polymorphism was the only variant significantly associated with VTE. 16362348 2006
dbSNP: rs121909607
rs121909607
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1260903
Disease:
Dysfibrinogenemia 		T 0.710 CausalMutation CLINVAR
dbSNP: rs121909607
rs121909607
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0553681
Disease:
Hypofibrinogenemia 		T 0.700 CausalMutation CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
dbSNP: rs121909607
rs121909607
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1458140
Disease:
Bleeding tendency 		T 0.700 CausalMutation CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
dbSNP: rs121909608
rs121909608
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0553681
Disease:
Hypofibrinogenemia 		C 0.700 GeneticVariation CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
dbSNP: rs146387238
rs146387238
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0553681
Disease:
Hypofibrinogenemia 		A 0.700 CausalMutation CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
dbSNP: rs2070006
rs2070006
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0042487
Disease:
Venous Thrombosis 		0.700 GeneticVariation GWASDB Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis. 22675575 2012
dbSNP: rs2070016
rs2070016
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1561955
Disease:
Fibrinogen, CTCAE 		0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs2070016
rs2070016
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1325327
Disease:
fibrinogen activity 		0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs2070016
rs2070016
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0337428
Disease:
Fibrinogen assay 		0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1325327
Disease:
fibrinogen activity 		C 0.700 GeneticVariation GWASDB Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease. 21757653 2011
dbSNP: rs6050
rs6050
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C1561955
Disease:
Fibrinogen, CTCAE 		C 0.700 GeneticVariation GWASDB Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease. 21757653 2011
dbSNP: rs121909606
rs121909606
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0272350
Disease:
Dysfibrinogenemia, Congenital 		0.700 GeneticVariation UNIPROT The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance. 16846481 2006
dbSNP: rs121909613
rs121909613
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0272350
Disease:
Dysfibrinogenemia, Congenital 		0.700 GeneticVariation UNIPROT The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance. 16846481 2006
dbSNP: rs121909606
rs121909606
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0272350
Disease:
Dysfibrinogenemia, Congenital 		0.700 GeneticVariation UNIPROT Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. 8473507 1993
dbSNP: rs121909613
rs121909613
Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C0272350
Disease:
Dysfibrinogenemia, Congenital 		0.700 GeneticVariation UNIPROT Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. 8473507 1993