R3HDM2, R3H domain containing 2, 22864

N. diseases: 24; N. variants: 17
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0409959
Disease:
Osteoarthritis, Knee 		0.010 GeneticVariation BEFREE With respect to gene-gene interactions, the pairwise interactions of rs112129861 (PDZK1) and rs7193778 (IGF1R); rs17050272 (INHBB) and rs1106766 (R3HDM2); rs1106766 (R3HDM2) and rs780093 (GCKR); rs1260326 (GCKR) and rs17786744 (STC1); and rs17786744 (STC1) and rs1106766 (R3HDM2) make it possible to visualize the synergistic or antagonistic effect of their genotypes or alleles on KOA development. 29855200 2019
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0022658
Disease:
Kidney Diseases 		0.010 GeneticVariation BEFREE We demonstrated that minor alleles of rs1106766 (intergenic, INHBC) were negatively associated with the risk of incident gout in subjects without renal disease, but not for individuals with renal disease. 26427508 2016
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension might imply a direct effect at the artery wall. 29989339 2018
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0020445
Disease:
Hypercholesterolemia, Familial 		0.010 GeneticVariation BEFREE The polymorphism rs11613352 may contribute to modulate the cardiovascular risk by modifying plasma lipid levels in familial hypercholesterolemia patients. 25278210 2015
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0745103
Disease:
Hyperlipoproteinemia Type IIa 		0.010 GeneticVariation BEFREE The polymorphism rs11613352 may contribute to modulate the cardiovascular risk by modifying plasma lipid levels in familial hypercholesterolemia patients. 25278210 2015
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Biological, clinical and population relevance of 95 loci for blood lipids. 20686565 2010
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0392885
Disease:
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Biological, clinical and population relevance of 95 loci for blood lipids. 20686565 2010
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		T 0.700 GeneticVariation GWASCAT Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0201976
Disease:
Creatinine measurement, serum (procedure) 		T 0.700 GeneticVariation GWASCAT Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 26831199 2016
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 26831199 2016
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1956346
Disease:
Coronary Artery Disease 		T 0.700 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs12313306
rs12313306
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs12313306
rs12313306
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		T 0.700 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs12315434
rs12315434
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1956346
Disease:
Coronary Artery Disease 		A 0.700 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs12315434
rs12315434
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12371805
rs12371805
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12371805
rs12371805
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2122982
rs2122982
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		A 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs4760355
rs4760355
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		G 0.700 GeneticVariation GWASCAT Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis. 31015462 2019