R3HDM2, R3H domain containing 2, 22864

N. diseases: 24; N. variants: 17
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0409959
Disease:
Osteoarthritis, Knee 		0.010 GeneticVariation BEFREE With respect to gene-gene interactions, the pairwise interactions of rs112129861 (PDZK1) and rs7193778 (IGF1R); rs17050272 (INHBB) and rs1106766 (R3HDM2); rs1106766 (R3HDM2) and rs780093 (GCKR); rs1260326 (GCKR) and rs17786744 (STC1); and rs17786744 (STC1) and rs1106766 (R3HDM2) make it possible to visualize the synergistic or antagonistic effect of their genotypes or alleles on KOA development. 29855200 2019
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE Association of low-density lipoprotein receptor-related protein 1 rs11613352 and angiopoietin-like 3 rs2131925 with hypertension might imply a direct effect at the artery wall. 29989339 2018
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0022658
Disease:
Kidney Diseases 		0.010 GeneticVariation BEFREE We demonstrated that minor alleles of rs1106766 (intergenic, INHBC) were negatively associated with the risk of incident gout in subjects without renal disease, but not for individuals with renal disease. 26427508 2016
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0020445
Disease:
Hypercholesterolemia, Familial 		0.010 GeneticVariation BEFREE The polymorphism rs11613352 may contribute to modulate the cardiovascular risk by modifying plasma lipid levels in familial hypercholesterolemia patients. 25278210 2015
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0745103
Disease:
Hyperlipoproteinemia Type IIa 		0.010 GeneticVariation BEFREE The polymorphism rs11613352 may contribute to modulate the cardiovascular risk by modifying plasma lipid levels in familial hypercholesterolemia patients. 25278210 2015
dbSNP: rs12313306
rs12313306
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs12313306
rs12313306
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		T 0.700 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs12315434
rs12315434
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0014772
Disease:
Red Blood Cell Count measurement 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12371805
rs12371805
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12371805
rs12371805
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2122982
rs2122982
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		A 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs4760355
rs4760355
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		G 0.700 GeneticVariation GWASCAT Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis. 31015462 2019
dbSNP: rs540730
rs540730
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs540730
rs540730
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		C 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs540730
rs540730
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0001948
Disease:
Alcohol consumption 		C 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs7974833
rs7974833
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs7974833
rs7974833
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. 31451708 2019
dbSNP: rs11613352
rs11613352
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1956346
Disease:
Coronary Artery Disease 		T 0.700 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs12315434
rs12315434
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C1956346
Disease:
Coronary Artery Disease 		A 0.700 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs540730
rs540730
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs61937595
rs61937595
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0036341
Disease:
Schizophrenia 		0.700 GeneticVariation GWASCAT Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. 29483656 2018
dbSNP: rs7971133
rs7971133
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C2985280
Disease:
Blood Protein Measurement 		T 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0201976
Disease:
Creatinine measurement, serum (procedure) 		T 0.700 GeneticVariation GWASCAT Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 26831199 2016
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. 26831199 2016
dbSNP: rs1106766
rs1106766
Entrez Id: 22864
Gene Symbol: R3HDM2
R3HDM2
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013