|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780).
|
23157339 |
2013 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The results showed that the T allele of rs1360780 was more frequent among the patients affected by MDD with a comorbidity of anxiety disorders, compared to those without (P < .001).
|
23861224 |
2013 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The significant interaction between ELA and the rs1360780 polymorphism in HATA suggests a role of FKBP5 in the pathophysiology of structural alterations in depression.
|
30986730 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The rs1360780 SNP in this gene (T allele vs C homozygous) has been found to be associated with major depressive disorder (MDD).
|
26076833 |
2016 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after psychosocial stress in healthy controls but not in remitted depression.
|
25522420 |
2014 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
We investigated the interactive effects of FKBP5 rs1360780 allelic variants, DNA methylation, and the diagnosis of MDD on structural changes of the entire brain.
|
28198448 |
2017 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress.
|
25522420 |
2014 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
FKBP5:rs1360780 allele T and genotype TT were overrepresented in depression for men.
|
20226536 |
2010 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of our study was to explore the role of the FKBP5 gene variants (rs1360780, rs3800373 and rs4713916), in depressive disorders or suicidal behavior through a systematic review and a meta-analysis.
|
30791339 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, P = 0.003, OR = 1.06, 95% CI = 1.02-1.11) and the rs3800373 C-allele (Z = 3.05, P = 0.002, OR = 1.07, 95% CI 1.02-1.12) were significantly associated with MDD in a fixed-effect model.
|
27601205 |
2016 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Third, there is an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk.
|
26801675 |
2017 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Given the large effect sizes, rs1360780 could be included into prediction models for depression in individuals exposed to childhood abuse.
|
21654733 |
2011 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression.
|
26645208 |
2016 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Change in FKBP5 expression correlated with change in Beck Depression Inventory (BDI) for MDD → euthymic comparison in GG genotype of rs3800373 (P = .013) and TT carriers of rs1360780 (P = .02).
|
20726698 |
2010 |
|
rs1360780
|
FKBP5;LOC112267956
|
Major Depressive Disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
We investigated the effects of the rs1360780 polymorphism of the hypothalamic-pituitary-axis related gene FKBP5 in combination with early life stress (ELA) on the structure of hippocampal subfields in MDD.
|
30986730 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressive disorder
|
|
0.090 |
GeneticVariation |
BEFREE |
Clinical association to FKBP5 rs1360780 in patients with depression.
|
31219960 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after psychosocial stress in healthy controls but not in remitted depression.
|
25522420 |
2014 |
|
rs1360780
|
FKBP5;LOC112267956
|
Depressed mood
|
|
0.080 |
GeneticVariation |
BEFREE |
Clinical association to FKBP5 rs1360780 in patients with depression.
|
31219960 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
Third, there is an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk.
|
26801675 |
2017 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
Clinical association to FKBP5 rs1360780 in patients with depression.
|
31219960 |
2019 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
Given the large effect sizes, rs1360780 could be included into prediction models for depression in individuals exposed to childhood abuse.
|
21654733 |
2011 |
|
rs1360780
|
FKBP5;LOC112267956
|
Mental Depression
|
|
0.080 |
GeneticVariation |
BEFREE |
The significant interaction between ELA and the rs1360780 polymorphism in HATA suggests a role of FKBP5 in the pathophysiology of structural alterations in depression.
|
30986730 |
2019 |