The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for glioma on chromosome 12p11.23 (rs10842893, p<sub>meta</sub> = 2.33x10-12, STK38L) as well as a promising association at 15q15-21.1 (rs4774756, p<sub>meta</sub> = 6.12x10-8, RAB27A) in 3,097 glioma cases and 4,362 controls.
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.