|
rs36119840
|
GDNF;GDNF-AS1
|
Adrenal Gland Pheochromocytoma
|
|
0.010 |
GeneticVariation |
BEFREE |
No GDNF mutations were identified in patients with familial phaeochromocytoma disease, but a c277C-->T (R93W) sequence variant was identified in one of 28 sporadic tumours.
|
9215674 |
1997 |
|
rs1227230819
|
GDNF;GDNF-AS1
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-base substitution was found in exon 1 (227G>A) of the XBP1 gene in a patient with diffuse large B-cell lymphoma, resulting in a somatic missense mutation (R76K).
|
19380033 |
2009 |
|
rs760097344
|
GDNF;GDNF-AS1
|
Amyotrophic Lateral Sclerosis
|
|
0.030 |
GeneticVariation |
BEFREE |
To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis (ALS), we transplanted hNPs or growth factor (GF)-expressing hNPs into the central nervous system (CNS) of mutant Cu/Zn superoxide dismutase (SOD1(G93A)) transgenic mice.
|
19322031 |
2009 |
|
rs760097344
|
GDNF;GDNF-AS1
|
Amyotrophic Lateral Sclerosis
|
|
0.030 |
GeneticVariation |
BEFREE |
Because adeno-associated virus (AAV) has been developed as an attractive gene delivery system with proven safety, we explored the therapeutic efficacy of intramuscular delivery of the GDNF gene mediated by an AAV vector (AAV-GDNF) in the G93A mouse model of ALS.
|
12177190 |
2002 |
|
rs760097344
|
GDNF;GDNF-AS1
|
Amyotrophic Lateral Sclerosis
|
|
0.030 |
GeneticVariation |
BEFREE |
Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors.
|
25641599 |
2017 |
|
rs11111
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs2973050
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample.
|
24324616 |
2013 |
|
rs3812047
|
GDNF;GDNF-AS1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males.
|
24324616 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs2973050
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, this is the first demonstration of a significant association between the GDNF gene and mood characteristics demonstrated by the association of two SNPs of the GDNF gene (rs3812047 and rs3096140) and individual variability of anxiety using self-report data from a non-clinical sample.
|
24324616 |
2013 |
|
rs3812047
|
GDNF;GDNF-AS1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males.
|
24324616 |
2013 |
|
rs11747340
|
GDNF;GDNF-AS1
|
Blood Protein Measurement
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.
|
31320639 |
2019 |
|
rs36119840
|
GDNF;GDNF-AS1
|
Congenital central hypoventilation
|
|
0.700 |
GeneticVariation |
UNIPROT |
An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management.
|
20208042 |
2010 |
|
rs36119840
|
GDNF;GDNF-AS1
|
Congenital central hypoventilation
|
|
0.700 |
GeneticVariation |
UNIPROT |
Mutations of the RET-GDNF signaling pathway in Ondine's curse.
|
9497256 |
1998 |
|
rs11111
|
GDNF;GDNF-AS1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of the allele-wise single marker association analyses provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p = 0.00070 and p = 0.00138 for rs3812047 and rs3096140, respectively), while no such result was obtained on depression scores.
|
24324616 |
2013 |
|
rs884344
|
GDNF;GDNF-AS1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |
|
rs11111
|
GDNF;GDNF-AS1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs3096140
|
GDNF;GDNF-AS1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Results of the allele-wise single marker association analyses provided significant effects of two single nucleotide polymorphisms on anxiety scores following the Bonferroni correction for multiple testing (p = 0.00070 and p = 0.00138 for rs3812047 and rs3096140, respectively), while no such result was obtained on depression scores.
|
24324616 |
2013 |
|
rs884344
|
GDNF;GDNF-AS1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |
|
rs1227230819
|
GDNF;GDNF-AS1
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-base substitution was found in exon 1 (227G>A) of the XBP1 gene in a patient with diffuse large B-cell lymphoma, resulting in a somatic missense mutation (R76K).
|
19380033 |
2009 |
|
rs36119840
|
GDNF;GDNF-AS1
|
Familial (FPAH)
|
|
0.010 |
GeneticVariation |
BEFREE |
No GDNF mutations were identified in patients with familial phaeochromocytoma disease, but a c277C-->T (R93W) sequence variant was identified in one of 28 sporadic tumours.
|
9215674 |
1997 |
|
rs884344
|
GDNF;GDNF-AS1
|
Heroin Dependence
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.
|
24022000 |
2013 |